Synthesis and characterization of poly(L-lactic acid) membranes: Studies in vivo and in vitro

dc.creatorLuciano, RM
dc.creatorZavaglia, CAC
dc.creatorDuek, EAR
dc.creatorAlberto-Rincon, MC
dc.date2003
dc.dateJAN
dc.date2014-11-19T06:07:11Z
dc.date2015-11-26T17:58:02Z
dc.date2014-11-19T06:07:11Z
dc.date2015-11-26T17:58:02Z
dc.date.accessioned2018-03-29T00:41:37Z
dc.date.available2018-03-29T00:41:37Z
dc.identifierJournal Of Materials Science-materials In Medicine. Kluwer Academic Publ, v. 14, n. 1, n. 87, n. 94, 2003.
dc.identifier0957-4530
dc.identifierWOS:000179704400012
dc.identifier10.1023/A:1021509722296
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74048
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/74048
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74048
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291640
dc.descriptionThe use of biodegradable polyesters as temporary structural supports in the recuperation of damaged live tissue is a promising area of research. Poly(L-lactic acid) (PLLA) membranes can act as a support for cell fixation and growth or as a barrier against soft tissues invasion in recuperating bone tissues. In this work, five different types of PLLA membranes, which varied in their polymer-solvent ratio and their content of plasticizer were studied. For the study in vivo, 6 mm diameter disks were inserted subcutaneously in the dorsal region of 15 Wistar rats, and the reactions on rats were studied 15 days later. In another series of experiments the samples were immersed in phosphate buffer, pH 7.4 at 37degreesC, for 30 days. Membranes without plasticizer were morphologically dense and did not allow cell invasion nor tissue adherence, in contrast to membranes with plasticizer. While porosity enhanced cell fixation and growth, it made the membrane more fragile mechanically when compared to membranes without pores. (C) 2003 Kluwer Academic Publishers.
dc.description14
dc.description1
dc.description87
dc.description94
dc.languageen
dc.publisherKluwer Academic Publ
dc.publisherDordrecht
dc.publisherHolanda
dc.relationJournal Of Materials Science-materials In Medicine
dc.relationJ. Mater. Sci.-Mater. Med.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectStructure Property Relationships
dc.subjectTissue Reaction
dc.subjectResorbable Polymers
dc.subjectInvitro Degradation
dc.subjectPhase-transitions
dc.subjectAqueous-media
dc.subjectIn-vitro
dc.subjectPolylactides
dc.subjectSystems
dc.subjectBiocompatibility
dc.titleSynthesis and characterization of poly(L-lactic acid) membranes: Studies in vivo and in vitro
dc.typeArtículos de revistas


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