Renal toxicity of Bothrops moojeni snake venom and its main myotoxins

dc.creatorBarbosa, PSF
dc.creatorHavt, A
dc.creatorFaco, PEG
dc.creatorSousa, TM
dc.creatorBezerra, ISAM
dc.creatorFonteles, MC
dc.creatorToyama, MH
dc.creatorMarangoni, S
dc.creatorNovello, JC
dc.creatorMonteiro, HSA
dc.date2002
dc.dateOCT
dc.date2014-11-19T04:40:06Z
dc.date2015-11-26T17:57:29Z
dc.date2014-11-19T04:40:06Z
dc.date2015-11-26T17:57:29Z
dc.date.accessioned2018-03-29T00:41:02Z
dc.date.available2018-03-29T00:41:02Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 40, n. 10, n. 1427, n. 1435, 2002.
dc.identifier0041-0101
dc.identifierWOS:000179136000005
dc.identifier10.1016/S0041-0101(02)00156-3
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70911
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70911
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70911
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291495
dc.descriptionAcute renal failure is one the most common systemic complications after snakebite, however, its pathogenesis remains obscure. In this study we evaluated the renal effects of Bothrops moojeni venom and its myotoxins (Bmtx-I and BmtxII) in rat isolated perfused kidneys. The myotoxins were purified by ion-exchange chromatography and reverse phase HPLC. The whole venom (10 mug/ml) and myotoxins (5 mug/ml) were added to the perfusion system 30 min after the beginning of each perfusion. The renal effects were compared to a control group perfused with modified Krebs-Henseleit solution alone. B. moojeni venom decreased the perfusion pressure (PP), renal vascular resistance (RVR), and the percent sodium, potassium and chloride tubular transport (%TNa+, %TK+, %TCl-). In contrast, the venom increased the urinary flow (UF), glomerular filtration rate (GFR), and the sodium, potassium and chloride excretion (ENa+, EK+, ECl-). The renal effects of myotoxin I was very similar to those of the whole venom, but there was an increase rather than a decrease in the PP and RVR. Myotoxin II had no effect on renal physiology, except for a transient decrease in %TK+. In conclusion, B. moojeni venom caused intense alterations in renal physiology, including a drop in vascular resistance associated with diuresis, natriuresis and kaliuresis. Bmtx-I had an opposite effect when compared to whole venom, showed in the parameters of PP and RVR. Bmtx-II had a mild effect in %TK+. The apparent inability of Bmtx-II to induce the renal effect similarly to Bmtx-I should be explained by the absence in the Bmtx-II of the C-terminal lysine rich region. (C) 2002 Elsevier Science Ltd. All rights reserved.
dc.description40
dc.description10
dc.description1427
dc.description1435
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBothrops moojeni
dc.subjectperfused kidney
dc.subjectmyotoxin
dc.subjectAmino-acid-sequence
dc.subjectBradykinin-potentiating Peptides
dc.subjectPhospholipase A(2) Homolog
dc.subjectRat-kidney
dc.subjectDurissus Cascavella
dc.subjectJararaca Venom
dc.subjectPiratoxin-ii
dc.titleRenal toxicity of Bothrops moojeni snake venom and its main myotoxins
dc.typeArtículos de revistas


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