INFLUENCE OF SUBACUTE STARVATION ON CARDIAC RESPONSE TO ISOPROTERENOL IN RATS

dc.creatorBASILE, A
dc.creatorCAMPOS, ACL
dc.creatorESTEVES, SC
dc.creatorBORDIN, S
dc.creatorMANTOVANI, M
dc.date1991
dc.dateJUL-AUG
dc.date2014-08-01T18:32:10Z
dc.date2015-11-26T17:57:14Z
dc.date2014-08-01T18:32:10Z
dc.date2015-11-26T17:57:14Z
dc.date.accessioned2018-03-29T00:40:46Z
dc.date.available2018-03-29T00:40:46Z
dc.identifierNutrition. Elsevier Science Inc, v. 7, n. 4, n. 280, n. 282, 1991.
dc.identifier0899-9007
dc.identifierWOS:A1991GF55300012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80369
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80369
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291429
dc.descriptionSeveral studies have reported that the heart is severely affected by chronic malnutrition. However, the influence of these alterations on cardiac function remains unclear. The aim of this study was to evaluate the effects of subacute starvation on the heart chronotropic response to a beta-adrenergic agonist (isoproterenol). Twelve rats were fed rat chow ad libitum or a 50%-restricted diet for 17 days. The rats were killed, the right atrium was isolated and incubated, and in vitro spontaneous cardiac contractions and frequency were registered. Cumulative doses of isoproterenol were added to the solution until maximal cardiac frequency was achieved. A deficit of 25% in the weight gain was observed in study rats compared with controls (92.6 +/- 10.2 vs. 113.8 +/- 19.2 g,p < 0.05). Mean daily food intake was 4.8 +/- 0.1 and 9.8 +/- 0.5 g/day for semistarved and control rats, respectively. The in vitro cardiac frequency of the semistarved rats was similar to that of controls (290 +/- 15 and 305 +/- 23 beats/min, respectively, NS). However, when isoproterenol was added to the solution, maximal cardiac frequency of the semistarved rats (435 +/- 51 beats/min) was lower than that of control rats (508 +/- 34 beats/min, p < 0.005). These findings suggest that subacute starvation may alter the cardiac response to beta-adrenergic agonists.
dc.description7
dc.description4
dc.description280
dc.description282
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.relationNutrition
dc.relationNutrition
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCARDIAC FUNCTION
dc.subjectSTARVATION
dc.subjectISOPROTERENOL
dc.subjectSympathetic Nervous-system
dc.subjectSensitivity
dc.subjectPacemaker
dc.subjectCatecholamines
dc.subjectMalnutrition
dc.subjectStress
dc.titleINFLUENCE OF SUBACUTE STARVATION ON CARDIAC RESPONSE TO ISOPROTERENOL IN RATS
dc.typeArtículos de revistas


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