Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile

dc.creatorAlbanez, R
dc.creatorNitz, M
dc.creatorTaranto, OP
dc.date2013
dc.dateMAY
dc.date2014-07-30T17:19:47Z
dc.date2015-11-26T17:56:53Z
dc.date2014-07-30T17:19:47Z
dc.date2015-11-26T17:56:53Z
dc.date.accessioned2018-03-29T00:40:28Z
dc.date.available2018-03-29T00:40:28Z
dc.identifierAdvanced Powder Technology. Elsevier Science Bv, v. 24, n. 3, n. 659, n. 666, 2013.
dc.identifier0921-8831
dc.identifierWOS:000323853500013
dc.identifier10.1016/j.apt.2012.12.003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64887
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64887
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291352
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe objective of this work was to study the coating process of diclofenac sodium pellets, with the commercial aqueous coating suspension for enteric release - Acryl-Eze (R) MP, in a fluid bed coater with a Wurster insert. Coating experiments were performed following a 2(2) factorial design to determine the influence of process variables on coating performance, measured by the two response variables: efficiency (eta(%)) and agglomeration index (m(agg%)). Both response variables were found to be affected by inlet temperature and suspension flow rate with a 95% confidence level. This work also studied the release of diclofenac sodium coated and uncoated pellets in HCl 0.1 N and pH 6.8 phosphate buffer media. Results showed that the release of diclofenac sodium during the buffer stage was affected by the prior exposure to the HCl 0.1 N medium and a polymer weight gain above 9.7% (2.7 mg/cm(2)), was needed to modify the release in such a way that it remained below 10% for the first 120 min in HCl 0.1 N and above 75% in pH 6.8 for the next 45 min. Neither the drug content nor the release profiles were significantly affected by storage at 40 degrees C and 75% relative humidity. (C) 2012 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.
dc.description24
dc.description3
dc.description659
dc.description666
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationAdvanced Powder Technology
dc.relationAdv. Powder Technol.
dc.rightsaberto
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCoating
dc.subjectPellets
dc.subjectFluidized bed
dc.subjectGastro-resistance
dc.subjectDiclofenac sodium
dc.subjectDrug-delivery System
dc.subjectDosage Forms
dc.subjectIn-vitro
dc.subjectDissolution
dc.subjectPolymers
dc.subjectDerivatives
dc.subjectParameters
dc.subjectMatrices
dc.subjectTablets
dc.subjectBlends
dc.titleEnteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile
dc.typeArtículos de revistas


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