dc.creator | Albanez, R | |
dc.creator | Nitz, M | |
dc.creator | Taranto, OP | |
dc.date | 2013 | |
dc.date | MAY | |
dc.date | 2014-07-30T17:19:47Z | |
dc.date | 2015-11-26T17:56:53Z | |
dc.date | 2014-07-30T17:19:47Z | |
dc.date | 2015-11-26T17:56:53Z | |
dc.date.accessioned | 2018-03-29T00:40:28Z | |
dc.date.available | 2018-03-29T00:40:28Z | |
dc.identifier | Advanced Powder Technology. Elsevier Science Bv, v. 24, n. 3, n. 659, n. 666, 2013. | |
dc.identifier | 0921-8831 | |
dc.identifier | WOS:000323853500013 | |
dc.identifier | 10.1016/j.apt.2012.12.003 | |
dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64887 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/64887 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1291352 | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | The objective of this work was to study the coating process of diclofenac sodium pellets, with the commercial aqueous coating suspension for enteric release - Acryl-Eze (R) MP, in a fluid bed coater with a Wurster insert. Coating experiments were performed following a 2(2) factorial design to determine the influence of process variables on coating performance, measured by the two response variables: efficiency (eta(%)) and agglomeration index (m(agg%)). Both response variables were found to be affected by inlet temperature and suspension flow rate with a 95% confidence level. This work also studied the release of diclofenac sodium coated and uncoated pellets in HCl 0.1 N and pH 6.8 phosphate buffer media. Results showed that the release of diclofenac sodium during the buffer stage was affected by the prior exposure to the HCl 0.1 N medium and a polymer weight gain above 9.7% (2.7 mg/cm(2)), was needed to modify the release in such a way that it remained below 10% for the first 120 min in HCl 0.1 N and above 75% in pH 6.8 for the next 45 min. Neither the drug content nor the release profiles were significantly affected by storage at 40 degrees C and 75% relative humidity. (C) 2012 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved. | |
dc.description | 24 | |
dc.description | 3 | |
dc.description | 659 | |
dc.description | 666 | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.language | en | |
dc.publisher | Elsevier Science Bv | |
dc.publisher | Amsterdam | |
dc.publisher | Holanda | |
dc.relation | Advanced Powder Technology | |
dc.relation | Adv. Powder Technol. | |
dc.rights | aberto | |
dc.rights | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dc.source | Web of Science | |
dc.subject | Coating | |
dc.subject | Pellets | |
dc.subject | Fluidized bed | |
dc.subject | Gastro-resistance | |
dc.subject | Diclofenac sodium | |
dc.subject | Drug-delivery System | |
dc.subject | Dosage Forms | |
dc.subject | In-vitro | |
dc.subject | Dissolution | |
dc.subject | Polymers | |
dc.subject | Derivatives | |
dc.subject | Parameters | |
dc.subject | Matrices | |
dc.subject | Tablets | |
dc.subject | Blends | |
dc.title | Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile | |
dc.type | Artículos de revistas | |