Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma

dc.creatorLima, CSP
dc.creatorNascimento, H
dc.creatorBonadia, LC
dc.creatorTeori, MT
dc.creatorCoy, CSR
dc.creatorGoes, JRN
dc.creatorCosta, FF
dc.creatorBertuzzo, CS
dc.date2007
dc.dateJUL
dc.date2014-11-19T03:32:14Z
dc.date2015-11-26T17:56:50Z
dc.date2014-11-19T03:32:14Z
dc.date2015-11-26T17:56:50Z
dc.date.accessioned2018-03-29T00:40:25Z
dc.date.available2018-03-29T00:40:25Z
dc.identifierInternational Journal Of Colorectal Disease. Springer, v. 22, n. 7, n. 757, n. 763, 2007.
dc.identifier0179-1958
dc.identifierWOS:000247316200005
dc.identifier10.1007/s00384-006-0237-z
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70728
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70728
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70728
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291340
dc.descriptionBackground and aims Evidence is accumulating for a role of folate in the aetiology of colorectal cancer (CRC). The methylenetetrahydrofolate reductase (MTHFR) gene, involved in folate metabolism, is polymorphic in humans. Since it is unknown whether the MTHFR C677T and A1298C polymorphisms alter the risk for CRC, this was the aim of our study. Materials and methods Genomic DNA from 102 sporadic colorectal adenocarcinoma (SCA) patients and 300 controls was analyzed by polymerase chain reaction followed by restriction digestion for the polymorphisms analyses. Results/findings The frequencies of MTHFR C677T and A1298C genotypes were similar in patients and controls. Similar overall risks for disease were seen in individuals with the distinct MTHFR genotypes. However, an excess of the MTHFR 677TT and 677CT genotypes was seen in patients under 50 years, compared with patients at an older age (19.2 vs 13.1% and 61.6 vs 39.5%, respectively; P=0.04). The differences were more prominent when the frequency of the 677TT plus 677CT genotype was seen in both group of patients (80.8 vs 52.6%, respectively; P=0.01), and in younger patients compared to controls (80.8 vs 52.3%, P < 0.01). Individuals with the combined genotype had 3.82-fold (95% confidence interval, 1.41-10.42) increased risk of developing SCA under 50 years, compared with those harboring the wild-type genotype. Interpretation/conclusion These results suggest a role for the MTHFR 677TT plus 677CT genotype in increasing SCA diagnosed at a low age in southeastern Brazil, but additional studies with larger sample sizes should be carried out to clarify this issue.
dc.description22
dc.description7
dc.description757
dc.description763
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationInternational Journal Of Colorectal Disease
dc.relationInt. J. Colorectal Dis.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectcolorectal cancer
dc.subjectepidemiology
dc.subjectMTHFR polymorphism
dc.subject5,10-methylenetetrahydrofolate Reductase
dc.subjectColon-cancer
dc.subjectDna Hypomethylation
dc.subjectFolate Metabolism
dc.subjectCommon Mutation
dc.subjectRisk
dc.subjectAssociation
dc.subjectCarcinogenesis
dc.subjectSusceptibility
dc.subjectMetaanalysis
dc.titlePolymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma
dc.typeArtículos de revistas


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