A Novel Phospholipase A(2) (D49) from the Venom of the Crotalus oreganus abyssus (North American Grand Canyon Rattlesnake)

dc.creatorMartins, W
dc.creatorBaldasso, PA
dc.creatorHonorio, KM
dc.creatorMaltarollo, VG
dc.creatorRibeiro, RIMA
dc.creatorCarvalho, BMA
dc.creatorSoares, AM
dc.creatorCalderon, LA
dc.creatorStabeli, RG
dc.creatorCaballol, MAO
dc.creatorAcosta, G
dc.creatorOliveira, E
dc.creatorMarangoni, S
dc.creatorAlbericio, F
dc.creatorDa Silva, SL
dc.date2014
dc.date2014-08-01T18:16:54Z
dc.date2015-11-26T17:56:48Z
dc.date2014-08-01T18:16:54Z
dc.date2015-11-26T17:56:48Z
dc.date.accessioned2018-03-29T00:40:24Z
dc.date.available2018-03-29T00:40:24Z
dc.identifierBiomed Research International. Hindawi Publishing Corporation, 2014.
dc.identifier2314-6133
dc.identifier2314-6141
dc.identifierWOS:000332721200001
dc.identifier10.1155/2014/654170
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76580
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76580
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291334
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCurrently, Crotalus viridis was divided into two species: Crotalus viridis and Crotalus oreganus. The current classification divides 'the old' Crotalus viridis into two new and independent species: Crotalus viridis (subspecies: viridis and nuntius) and Crotalus oreganus (subspecies: abyssus, lutosus, concolor, oreganus, helleri, cerberus, and caliginis). The analysis of a product from cDNA (E6d), derived from the gland of a specie Crotalus viridis viridis, was found to produce an acid phospholipase A(2). In this study we isolated and characterized a PLA(2) (D49) from Crotalus oreganus abyssus venom. Our studies show that the PLA(2) produced from the cDNA of Crotalus viridis viridis (named E6d) is exactly the same PLA(2) primary sequence of amino acids isolated from the venom of Crotalus oreganus abyssus. Thus, the PLA(2) from E6d cDNA is actually the same PLA(2) presented in the venom of Crotalus oreganus abyssus and does not correspond to the venom from Crotalus viridis viridis. These facts highlight the importance of performing more studies on subspecies of Crotalus oreganus and Crotalus viridis, since the old classification may have led to mixed results or mistaken data.
dc.descriptionMinistry of Science and Technology (MCTI)
dc.descriptionFinanciadora de Estudos e Projetos (FINEP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionInstituto Nacional para Pesquisa em Toxinas (INCT-Tox)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherHindawi Publishing Corporation
dc.publisherNew York
dc.publisherEUA
dc.relationBiomed Research International
dc.relationBiomed Res. Int.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectBothrops Snake-venoms
dc.subjectWestern Rattlesnake
dc.subject3-dimensional Structures
dc.subjectNatriuretic Peptide
dc.subjectIsolated Toxins
dc.subjectViridis
dc.subjectMice
dc.subjectInhibitors
dc.subjectDisease
dc.subjectRecognition
dc.titleA Novel Phospholipase A(2) (D49) from the Venom of the Crotalus oreganus abyssus (North American Grand Canyon Rattlesnake)
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución