MORPHOMETRIC INVESTIGATIONS OF THE COLON MUCOSA IN CHRONIC TRYPANOSOMA-CRUZI INFECTED-RATS

dc.creatorFERNANDES, MIM
dc.creatorZUCOLOTO, S
dc.creatorCOLLARES, EF
dc.creatorFILHO, FF
dc.date1991
dc.date2014-12-16T11:33:51Z
dc.date2015-11-26T17:56:38Z
dc.date2014-12-16T11:33:51Z
dc.date2015-11-26T17:56:38Z
dc.date.accessioned2018-03-29T00:40:15Z
dc.date.available2018-03-29T00:40:15Z
dc.identifierVirchows Archiv B-cell Pathology Including Molecular Pathology. Springer Verlag, v. 60, n. 2, n. 119, n. 122, 1991.
dc.identifier0340-6075
dc.identifierWOS:A1991FG96000007
dc.identifier10.1007/BF02899536
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/82255
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/82255
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/82255
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291295
dc.descriptionThe objective of this investigation was to study the morphometry of the epithelial mucosa in the chronic phase of T. cruzi infection. Nine young female Wistar rats were inoculated with T. cruzi. Ten months after inoculation the animals were sacrificed and the proximal colon was collected for morphometric measurements of the thickness of the muscle layers, the number of neurons in the myenteric plexus, the crypt cell population (CCP), crypt cell production per crypt (CCPC) and turnover time (TT) of the epithelium. There was no muscle layer hypertrophy but there was significant denervation in the group inoculated with T. cruzi, which also showed hyperplasia of the epithelium. The data suggest that denervation of the myenteric plexus did not induce hypertrophy of the propria muscle layer itself but altered the morphometry of the colonic epithelium in T. cruzi-infected animals, with increased development of CCP and TT. It is possible that this epithelial hyperplasia, as a consequence of a longer crypt cell TT, increased the absorption and secretion activities of the colon, which in turn may participate in the genesis of the enteromegalies observed in the chronic phase of Chagas' Disease.
dc.description60
dc.description2
dc.description119
dc.description122
dc.languageen
dc.publisherSpringer Verlag
dc.publisherNew York
dc.relationVirchows Archiv B-cell Pathology Including Molecular Pathology
dc.relationVirchows Arch. B-Cell Molec. Pathol.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectCHAGAS DISEASE
dc.subjectEPITHELIAL MORPHOLOGICAL
dc.subjectCOLON-CHRONIC PHASE
dc.subjectDENERVATION OF THE MYENTERIC PLEXUS
dc.subjectCell-proliferation
dc.subjectChemical Ablation
dc.subjectMyenteric Neurons
dc.subjectEpithelium
dc.subjectDenervation
dc.subjectJejunum
dc.titleMORPHOMETRIC INVESTIGATIONS OF THE COLON MUCOSA IN CHRONIC TRYPANOSOMA-CRUZI INFECTED-RATS
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución