Default Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease

dc.creatorWeiler, M
dc.creatorFukuda, A
dc.creatorMassabki, LHP
dc.creatorLopes, TM
dc.creatorFranco, AR
dc.creatorDamasceno, BP
dc.creatorCendes, F
dc.creatorBalthazar, MLF
dc.date2014
dc.dateMAR
dc.date2014-08-01T18:28:02Z
dc.date2015-11-26T17:56:28Z
dc.date2014-08-01T18:28:02Z
dc.date2015-11-26T17:56:28Z
dc.date.accessioned2018-03-29T00:40:05Z
dc.date.available2018-03-29T00:40:05Z
dc.identifierCurrent Alzheimer Research. Bentham Science Publ Ltd, v. 11, n. 3, n. 274, n. 282, 2014.
dc.identifier1567-2050
dc.identifier1875-5828
dc.identifierWOS:000334058100008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79364
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79364
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291255
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionAlzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory performance.
dc.description11
dc.description3
dc.description274
dc.description282
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2011/17092-0, 2013/10431-9]
dc.languageen
dc.publisherBentham Science Publ Ltd
dc.publisherSharjah
dc.publisherEmirados Árabes Unidos
dc.relationCurrent Alzheimer Research
dc.relationCurr. Alzheimer Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectAlzheimer's disease
dc.subjectcognition
dc.subjectdefault mode network
dc.subjectfunctional connectivity
dc.subjectfunctional networks
dc.subjectresting-state networks
dc.subjectResting-state Networks
dc.subjectCognitive Impairment
dc.subjectBrain
dc.subjectDisruption
dc.subjectFmri
dc.subjectIndividuals
dc.subjectProgression
dc.subjectDementia
dc.subjectAtrophy
dc.subjectThought
dc.titleDefault Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease
dc.typeArtículos de revistas


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