| dc.creator | Gomes, PAP | |
| dc.creator | Bassani, RA | |
| dc.creator | Bassani, JWM | |
| dc.date | 2001 | |
| dc.date | JUN | |
| dc.date | 2014-11-19T02:32:59Z | |
| dc.date | 2015-11-26T17:56:17Z | |
| dc.date | 2014-11-19T02:32:59Z | |
| dc.date | 2015-11-26T17:56:17Z | |
| dc.date.accessioned | 2018-03-29T00:39:56Z | |
| dc.date.available | 2018-03-29T00:39:56Z | |
| dc.identifier | Ieee Transactions On Biomedical Engineering. Ieee-inst Electrical Electronics Engineers Inc, v. 48, n. 6, n. 630, n. 636, 2001. | |
| dc.identifier | 0018-9294 | |
| dc.identifier | WOS:000168780400003 | |
| dc.identifier | 10.1109/10.923781 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65435 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/65435 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/65435 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1291217 | |
| dc.description | Studies on cardiac cell response to electric field stimulation are important for understanding basic phenomena underlying cardiac defibrillation, In this work, we used a model of a prolate spheroidal cell in a uniform external field (Klee and Plonsey, 1976) to predict the threshold electric field (E-T) for stimulation of isolated ventricular myocytes of rats at different ages. The model assumes that E-T is primarily determined by cell shape and dimensions, which markedly change during postnatal development, Neonatal cells showed very high E-T, which progressively decreased with maturation (experimental mean values were 29, 21, 13, and 5.9 and 6.3 V/cm for 3-6, 13-16, 20-21, 28-35, and 120-180 day-old rats, respectively, P < 0.001; theoretical values were 24, 18, 11, 9, and 6 V/cm, respectively). Estimated maximum membrane depolarization at threshold (<Delta>V-T approximate to 35 mV, under our experimental conditions) was reasonably constant during development, except for cells from 1-mo-old animals, in which DeltaV(T) was lower than at other ages. We conclude that the model reasonably correlates E-T with cell geometry and size in most cases, Our results might be relevant for the development of efficient procedures for defibrillation of pediatric patients. | |
| dc.description | 48 | |
| dc.description | 6 | |
| dc.description | 630 | |
| dc.description | 636 | |
| dc.language | en | |
| dc.publisher | Ieee-inst Electrical Electronics Engineers Inc | |
| dc.publisher | New York | |
| dc.publisher | EUA | |
| dc.relation | Ieee Transactions On Biomedical Engineering | |
| dc.relation | IEEE Trans. Biomed. Eng. | |
| dc.rights | fechado | |
| dc.rights | http://www.ieee.org/publications_standards/publications/rights/rights_policies.html | |
| dc.source | Web of Science | |
| dc.subject | excitation threshold | |
| dc.subject | membrane depolarization | |
| dc.subject | modeling | |
| dc.subject | Liminal Length | |
| dc.subject | Muscle | |
| dc.subject | Cells | |
| dc.subject | Excitation | |
| dc.title | Electric field stimulation of cardiac myocytes during postnatal development | |
| dc.type | Artículos de revistas | |
