Brasil | Artículos de revistas

Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus

dc.creatorTavares, TG
dc.creatorMonteiro, KM
dc.creatorPossenti, A
dc.creatorPintado, ME
dc.creatorCarvalho, JE
dc.creatorMalcata, FX
dc.date2011
dc.dateDEC
dc.date2014-08-01T18:22:28Z
dc.date2015-11-26T17:55:15Z
dc.date2014-08-01T18:22:28Z
dc.date2015-11-26T17:55:15Z
dc.date.accessioned2018-03-29T00:39:03Z
dc.date.available2018-03-29T00:39:03Z
dc.identifierInternational Dairy Journal. Elsevier Sci Ltd, v. 21, n. 12, n. 934, n. 939, 2011.
dc.identifier0958-6946
dc.identifierWOS:000295830900005
dc.identifier10.1016/j.idairyj.2011.06.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77989
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77989
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290993
dc.descriptionPeptide concentrates generated by hydrolysis of whey with aqueous extracts of flowers of Cynara cardunculus were studied for possible protection of the stomach mucosa against ulcerative lesions caused by oral administration of absolute ethanol. Both the whole peptide fraction obtained via hydrolysis of whey protein concentrate (peptide concentrate, PepC) and its fraction below 3 kDa (PepCF) were able to reduce gastric injuries to significant levels (p < 0.05). Single-dose experiments, using 100 mg kg(-1) body weight (bw) of either PepCF or PepC, led to 68.5% and 37.4% protection, respectively - which compare well with 93.4% protection by 200 mg kg (1) bw carbenoxolone (a positive control). No dose-response correlation could be demonstrated. Gastric cytoprotection by PepCF appears to depend on sulphydryl-containing moieties, whereas PepC likely protects the gastric mucosa via the prostaglandin cycle and production of nitric oxide. (c) 2011 Published by Elsevier Ltd.
dc.description21
dc.description12
dc.description934
dc.description939
dc.descriptionCYTED
dc.description[SFRH/BD/31604/2006]
dc.description[SFRH/BD/31604/2006]
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationInternational Dairy Journal
dc.relationInt. Dairy J.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBovine Alpha-lactalbumin
dc.subjectGastroduodenal Mucosal Protection
dc.subjectHighly Activated Supports
dc.subjectMilk-proteins
dc.subjectCardosin-a
dc.subjectEnzymatic-hydrolysis
dc.subjectRats
dc.subjectProstaglandins
dc.subjectMechanisms
dc.subjectCytoprotection
dc.titleAntiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus
dc.typeArtículos de revistas


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