| dc.creator | WILLIAMS, O | |
| dc.creator | AROEIRA, LS | |
| dc.creator | MENGEL, J | |
| dc.date | 1995 | |
| dc.date | SEP | |
| dc.date | 2014-12-16T11:33:34Z | |
| dc.date | 2015-11-26T17:54:49Z | |
| dc.date | 2014-12-16T11:33:34Z | |
| dc.date | 2015-11-26T17:54:49Z | |
| dc.date.accessioned | 2018-03-29T00:38:32Z | |
| dc.date.available | 2018-03-29T00:38:32Z | |
| dc.identifier | Scandinavian Journal Of Immunology. Blackwell Science Ltd, v. 42, n. 3, n. 305, n. 310, 1995. | |
| dc.identifier | 0300-9475 | |
| dc.identifier | WOS:A1995RR54000003 | |
| dc.identifier | 10.1111/j.1365-3083.1995.tb03660.x | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78727 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/78727 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/78727 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1290870 | |
| dc.description | Treatment of mice with staphylococcal enterotoxin B (SEB) induces specific T-cell tolerance to this superantigen, characterized by partial deletion of V beta 8(+) T cells in vivo and T cell anergy in vitro. In this study we examined the humoral response to SEB in BALB/c mice. Immunization of mice with SEB results in a detectable anti-SEB antibody response. Upon further treatment of mice with SEB, specific antibody levels increase significantly and the response is accelerated-characteristics of a secondary humoral response. The secondary antibody response is T cell dependent, can be transferred to T cell deficient mice with splenocytes and is composed mainly of IgM, IgGI and IgG2b isotypes, suggesting that Th2 cells provide B cell help in this response. These data demonstrate that at the same time as inducing in vitro unresponsiveness, SEB primes SEB-specific T helper cells to provide help for B cells in a secondary antibody response. | |
| dc.description | 42 | |
| dc.description | 3 | |
| dc.description | 305 | |
| dc.description | 310 | |
| dc.language | en | |
| dc.publisher | Blackwell Science Ltd | |
| dc.publisher | Oxford | |
| dc.publisher | Inglaterra | |
| dc.relation | Scandinavian Journal Of Immunology | |
| dc.relation | Scand. J. Immunol. | |
| dc.rights | fechado | |
| dc.source | Web of Science | |
| dc.subject | Bacterial Superantigens | |
| dc.subject | In-vivo | |
| dc.subject | Invivo | |
| dc.subject | Anergy | |
| dc.subject | Deletion | |
| dc.subject | Mice | |
| dc.subject | Induction | |
| dc.subject | Lymphocytes | |
| dc.subject | Tolerance | |
| dc.subject | Death | |
| dc.title | T-CELL-DEPENDENT ANTIBODY-RESPONSE TO STAPHYLOCOCCAL-ENTEROTOXIN-B | |
| dc.type | Artículos de revistas | |
