Relationship between adiponectin and nitrite in healthy and preeclampsia pregnancies

dc.creatorEleuterio, NM
dc.creatorPalei, ACT
dc.creatorMachado, JSR
dc.creatorTanus-Santos, JE
dc.creatorCavalli, RC
dc.creatorSandrim, VC
dc.date2013
dc.dateAUG 23
dc.date2014-08-01T18:31:05Z
dc.date2015-11-26T17:54:49Z
dc.date2014-08-01T18:31:05Z
dc.date2015-11-26T17:54:49Z
dc.date.accessioned2018-03-29T00:38:32Z
dc.date.available2018-03-29T00:38:32Z
dc.identifierClinica Chimica Acta. Elsevier Science Bv, v. 423, n. 112, n. 115, 2013.
dc.identifier0009-8981
dc.identifierWOS:000320976100021
dc.identifier10.1015/j.cca.2013.04.027
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80097
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80097
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290868
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: Controversial results have been reported regarding plasma adiponectin levels in preeclampsia (PE) compared to healthy pregnancies (HP). Adiponectin activates eNOS, increasing the levels of the vasodilator nitric oxide (NO). PE reduces the levels of nitrite (an NO marker) and induces higher levels of ADMA (an endogenous eNOS inhibitor) compared to HP. No previous study has examined whether a positive correlation exists between adiponectin and nitrite in HP and PE and how ADMA may interfere with this correlation. Methods: We measured plasma nitrite concentrations using an ozone-based chemiluminescence assay, and plasma ADMA and adiponectin levels using enzyme immunoassays in 117 pregnant women (70 healthy and 47 preeclamptic). Results: We found higher adiponectin levels (23.6 +/- 13.0 vs. 17.8 +/- 5.6 mu g/ml; P < 0.05) and lower plasma nitrite levels (104.5 +/- 843 vs. 1772 +/- 151.3 nM; P < 0.05) in PE compared to HP. We found a significant positive correlation between these markers in HP (r = 03; P < 0.05), but no correlation in PE. However, when we grouped PE women regarding ADMA levels (low and high levels), a strong positive correlation was found in the group with lower ADMA levels (r = 0.67; P < 0.05), suggesting that high ADMA concentrations may interfere with the physiological activation of eNOS by adiponectin in PE. Conclusions: Our findings showed higher levels of adiponectin and lower nitrite levels in PE compared to HP, and these levels were positively correlated in HP and in PE presenting lower concentrations of ADMA. (C) 2013 Elsevier B.V. All rights reserved.
dc.description423
dc.description112
dc.description115
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionInstituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte (IEP-SCBH)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationClinica Chimica Acta
dc.relationClin. Chim. Acta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAdiponectin
dc.subjectADMA
dc.subjectNitric oxide
dc.subjectNO
dc.subjectPreeclampsia
dc.subjectCirculating Angiogenic Factors
dc.subjectMolecular-weight Adiponectin
dc.subjectOxide Synthase Activity
dc.subjectPlasma-concentrations
dc.subjectEndogenous Inhibitor
dc.subjectWomen
dc.subjectSerum
dc.subjectHypoadiponectinemia
dc.subjectAssociation
dc.subjectIncrease
dc.titleRelationship between adiponectin and nitrite in healthy and preeclampsia pregnancies
dc.typeArtículos de revistas


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