Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects

dc.creatorPio-Magalhaes, JA
dc.creatorFerreira-Sae, MC
dc.creatorSouza, FA
dc.creatorGrespan-Magossi, AM
dc.creatorSchreiber, R
dc.creatorVelloso, LA
dc.creatorGeloneze, B
dc.creatorFranchini, KG
dc.creatorNadruz, W
dc.date2011
dc.dateOCT
dc.date2014-08-01T18:30:55Z
dc.date2015-11-26T17:54:19Z
dc.date2014-08-01T18:30:55Z
dc.date2015-11-26T17:54:19Z
dc.date.accessioned2018-03-29T00:37:57Z
dc.date.available2018-03-29T00:37:57Z
dc.identifierJournal Of Endocrinological Investigation. Editrice Kurtis S R L, v. 34, n. 9, n. 680, n. 684, 2011.
dc.identifier0391-4097
dc.identifierWOS:000299404800006
dc.identifier10.3275/7725
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80019
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80019
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290759
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAim: This report investigated the relationship between anthropometric measurements of body fat distribution and lipid response to statins in hypercholesterolemic hypertensive patients. Methods: We prospectively examined 129 subjects who used either simvastatin 20 mg/day (no.=83) or atorvastatin 10 mg/day (no.=46) for 3 months. Anthropometry included evaluation of body mass index, waist and hip circumferences, and waist-to-hip-ratio. Results: Significant decreases in LDL (p<0.001), total cholesterol (p<0.001), and triglycerides (p=0.04) levels were detected after 3 months of therapy in the whole sample. At baseline, only an inverse correlation between waist circumference and HDL-cholesterol levels was detected (r=-0.18; p=0.04). Conversely, a direct relationship between hip circumference and HDL-cholesterol response to statins was found in the whole sample (r=0.24; p=0.006), while no other anthropometric measurement displayed significant correlation with lipid changes. The association between HDL-cholesterol response and hip circumference was further confirmed by stepwise regression analysis adjusted for baseline HDL-cholesterol levels, metabolic syndrome, body mass index, and waist circumference. Conclusions: Hip circumference, a surrogate marker of peripheral adiposity, is associated with HDL-cholesterol changes following statin therapy in hypertensive patients. (J. Endocrinol. Invest. 34: 680-684, 2011) (C) 2011, Editrice Kurtis
dc.description34
dc.description9
dc.description680
dc.description684
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [Proc. 05/56986-5]
dc.descriptionCNPq [Proc. 304329/06-1, 474206/07-6]
dc.languageen
dc.publisherEditrice Kurtis S R L
dc.publisherMilan
dc.publisherItália
dc.relationJournal Of Endocrinological Investigation
dc.relationJ. Endocrinol. Invest.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectAtorvastatin
dc.subjectHDL-cholesterol
dc.subjecthip circumference
dc.subjecthypertension
dc.subjectsimvastatin
dc.subjectMetabolic-syndrome
dc.subjectHeart-disease
dc.subjectSimvastatin
dc.subjectWomen
dc.subjectAtorvastatin
dc.subjectPredictors
dc.subjectPhenotypes
dc.subjectTrial
dc.subjectWaist
dc.titleHip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects
dc.typeArtículos de revistas


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