STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE-HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS

dc.creatorCAPUCCI, MS
dc.creatorHOFFMANN, ME
dc.creatorNATARAJAN, AT
dc.date1995
dc.dateJUL
dc.date2014-12-16T11:33:24Z
dc.date2015-11-26T17:53:43Z
dc.date2014-12-16T11:33:24Z
dc.date2015-11-26T17:53:43Z
dc.date.accessioned2018-03-29T00:37:18Z
dc.date.available2018-03-29T00:37:18Z
dc.identifierMutation Research Letters. Elsevier Science Bv, v. 347, n. 2, n. 79, n. 85, 1995.
dc.identifier0165-7992
dc.identifierWOS:A1995RN22200005
dc.identifier10.1016/0165-7992(95)90074-8
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75172
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75172
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75172
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290600
dc.descriptionThe genotoxic effects of the methylating agent streptozotocin (STZ) on Chinese hamster cells CHO-9 and V79 were evaluated. The induction of cell killing, chromosomal aberrations, sister-chromatid exchanges (SCEs) and mutations was analyzed. Comparisons were made with the the STZ aglyconic analogue N-methyl-N-nitrosourea (MNU). V79 cells were found to be more resistant than CHO-9 cells to STZ and MNU killing effects, as well as to the induction of chromosomal aberrations and SCEs; however, V79 and CHO-9 cells appeared to be equally sensitive to the induction of 6-thioguanine resistant mutants by STZ. These results suggest that an error-free mechanism that tolerates DNA methylation damage confers a resistant phenotype to V79 cells to the genotoxic effects of methylation damage.
dc.description347
dc.description2
dc.description79
dc.description85
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationMutation Research Letters
dc.relationMutat. Res. Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectSTREPTOZOTOCIN
dc.subjectMETHYLNITROSOUREA
dc.subjectCHINESE HAMSTER CELLS
dc.subjectCHROMOSOMAL ABERRATION
dc.subjectSISTER-CHROMATID EXCHANGE
dc.subjectMUTATION
dc.subjectSister-chromatid Exchanges
dc.subjectDna
dc.subjectMethylnitrosourea
dc.subject6-thioguanine
dc.subjectNitrosourea
dc.subjectDamage
dc.subjectRepair
dc.subjectAgents
dc.titleSTREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE-HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS
dc.typeArtículos de revistas


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