ANTI-INFLAMMATORY ACTIVITY OF Blutaparon portulacoides ETHANOLIC EXTRACT AGAINST THE INFLAMMATORY REACTION INDUCED BY Bothrops jararacussu VENOM AND ISOLATED MYOTOXINS BthTX-I AND II

dc.creatorPereira, IC
dc.creatorBarbosa, AM
dc.creatorSalvador, MJ
dc.creatorSoares, AM
dc.creatorRibeiro, W
dc.creatorCogo, JC
dc.creatorZamuner, SR
dc.date2009
dc.date2014-08-01T18:22:02Z
dc.date2015-11-26T17:53:39Z
dc.date2014-08-01T18:22:02Z
dc.date2015-11-26T17:53:39Z
dc.date.accessioned2018-03-29T00:37:14Z
dc.date.available2018-03-29T00:37:14Z
dc.identifierJournal Of Venomous Animals And Toxins Including Tropical Diseases. Cevap-unesp, v. 15, n. 3, n. 527, n. 545, 2009.
dc.identifier1678-9199
dc.identifierWOS:000270417000013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77794
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77794
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290582
dc.descriptionThis article reports the anti-inflammatory effect of Blutaparon portulacoides (B. portulacoides), specifically the ethanolic extract of its aerial parts, on the edema formation and leukocyte influx caused by Bothrops jararacussu (B. jararacussu) snake venom and Bothropstoxin-I and II (BthTX-I and II) isolated from this venom as an alternative treatment for Bothrops snakebites. The anti-inflammatory effect of B. portulacoides ethanolic extract was compared with an animal group pretreated with dexamethasone. B. portulacoides ethanolic extract significantly inhibited paw edema induced by B. jararacussu venom and by BthTX-I and II. Also, results demonstrated that the extract caused a reduction of the leukocyte influx induced by BthTX-I. However, the extract was not capable of inhibiting the leukocyte influx induced by the venom and by BthTX-II. In conclusion, these results suggest that the ethanolic extract of this plant possess components able to inhibit or inactivate toxins present in B. jararacussu venom, including its myotoxins, responsible for the edema formation. However, the leukocyte migration caused by the venom and BthTX-II was not inhibited by the plant, probably due to the different mechanisms involved in the edema formation and leukocyte influx. This is the first report of B. portulacoides extract as anti-inflammatory against snake venoms and isolated toxins.
dc.description15
dc.description3
dc.description527
dc.description545
dc.languageen
dc.publisherCevap-unesp
dc.publisherBotucatu
dc.publisherBrasil
dc.relationJournal Of Venomous Animals And Toxins Including Tropical Diseases
dc.relationJ. Venom. Anim. Toxins Trop. Dis.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectBothrops jararacussu
dc.subjectmyotoxins
dc.subjectinflammation
dc.subjectedema
dc.subjectBlutaparon portulacoides
dc.subjectCasearia-sylvestris Flacourtiaceae
dc.subjectSnake-venom
dc.subjectAqueous Extract
dc.subjectPhospholipases A(2)
dc.subjectAntiophidian Properties
dc.subjectBiological-activity
dc.subjectAsper Venom
dc.subjectSao-paulo
dc.subjectNeutralization
dc.subjectInhibition
dc.titleANTI-INFLAMMATORY ACTIVITY OF Blutaparon portulacoides ETHANOLIC EXTRACT AGAINST THE INFLAMMATORY REACTION INDUCED BY Bothrops jararacussu VENOM AND ISOLATED MYOTOXINS BthTX-I AND II
dc.typeArtículos de revistas


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