A low-protein diet during pregnancy alters glucose metabolism and insulin secretion

dc.creatorSouza, DDI
dc.creatorIgnacio-Souza, LM
dc.creatorReis, SRD
dc.creatorReis, MAD
dc.creatorStoppiglia, LF
dc.creatorCarneiro, EM
dc.creatorBoschero, AC
dc.creatorArantes, VC
dc.creatorLatorraca, MQ
dc.date2012
dc.dateMAR
dc.date2014-08-01T18:14:45Z
dc.date2015-11-26T17:53:38Z
dc.date2014-08-01T18:14:45Z
dc.date2015-11-26T17:53:38Z
dc.date.accessioned2018-03-29T00:37:14Z
dc.date.available2018-03-29T00:37:14Z
dc.identifierCell Biochemistry And Function. Wiley-blackwell, v. 30, n. 2, n. 114, n. 121, 2012.
dc.identifier0263-6484
dc.identifierWOS:000301116100005
dc.identifier10.1002/cbf.1824
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76025
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76025
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290580
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn pancreatic islets, glucose metabolism is a key process for insulin secretion, and pregnancy requires an increase in insulin secretion to compensate for the typical insulin resistance at the end of this period. Because a low-protein diet decreases insulin secretion, this type of diet could impair glucose homeostasis, leading to gestational diabetes. In pancreatic islets, we investigated GLUT2, glucokinase and hexokinase expression patterns as well as glucose uptake, utilization and oxidation rates. Adult control non-pregnant (CNP) and control pregnant (CP) rats were fed a normal protein diet (17%), whereas low-protein non-pregnant (LPNP) and low-protein pregnant (LPP) rats were fed a low-protein diet (6%) from days 1 to 15 of pregnancy. The insulin secretion in 2.8?mmol l-1 of glucose was higher in islets from LPP rats than that in islets from CP, CNP and LPNP rats. Maximal insulin release was obtained at 8.3 and 16.7?mmol l-1 of glucose in LPP and CP groups, respectively. The glucose doseresponse curve from LPNP group was shifted to the right in relation to the CNP group. In the CP group, the concentrationresponse curve to glucose was shifted to the left compared with the CNP group. The LPP groups exhibited an inverted U-shape doseresponse curve. The alterations in the GLUT2, glucokinase and hexokinase expression patterns neither impaired glucose metabolism nor correlated with glucose islet sensitivity, suggesting that beta-cell sensitivity to glucose requires secondary events other than the observed metabolic/molecular events. Copyright (c) 2011 John Wiley & Sons, Ltd.
dc.description30
dc.description2
dc.description114
dc.description121
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Mato Grosso [0786/2006]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundacao de Amparo a Pesquisa do Estado de Mato Grosso [0786/2006]
dc.descriptionCNPq [305155/2004-0]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationCell Biochemistry And Function
dc.relationCell Biochem. Funct.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectlow-protein diet
dc.subjectpregnancy
dc.subjectglucose metabolism
dc.subjectpancreatic islets
dc.subjectinsulin secretion
dc.subjectPancreatic-beta-cells
dc.subjectUp-regulation
dc.subjectHexokinase-i
dc.subjectRat Islets
dc.subjectGlucokinase
dc.subjectLangerhans
dc.subjectProlactin
dc.subjectOverexpression
dc.subjectAdaptation
dc.subjectExpression
dc.titleA low-protein diet during pregnancy alters glucose metabolism and insulin secretion
dc.typeArtículos de revistas


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