Cytosolic thioredoxin peroxidase I is essential for the antioxidant defense of yeast with dysfunctional mitochondria

dc.creatorDemasi, APD
dc.creatorPereira, GAG
dc.creatorNetto, LES
dc.date2001
dc.dateDEC 14
dc.date2014-11-18T18:23:53Z
dc.date2015-11-26T17:53:07Z
dc.date2014-11-18T18:23:53Z
dc.date2015-11-26T17:53:07Z
dc.date.accessioned2018-03-29T00:36:40Z
dc.date.available2018-03-29T00:36:40Z
dc.identifierFebs Letters. Elsevier Science Bv, v. 509, n. 3, n. 430, n. 434, 2001.
dc.identifier0014-5793
dc.identifierWOS:000172949600017
dc.identifier10.1016/S0014-5793(01)03215-X
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57616
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57616
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57616
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290438
dc.descriptionThe specific role of cytosolic thioredoxin peroxidase I (cTPx I), encoded by TSA1 (thiol-speciric antioxidant), was investigated in the oxidative stress response of Saccharomyces ceravisiae. In most cases, deletion of TSA1 has showed only a slight effect on hydrogen peroxide sensitivity. However, when the functional state of the mitochondria was compromised, the necessity of TSA1 in cell protection against this oxidant was much more evident. All the procedures used to disrupt the mitochondrial respiratory chain promoted increases in the generation of H2O2 in Cells, which could be related to their elevated sensitivity to oxidative stress. In. fact, TSA1 is highly expressed when cells with respiratory deficiency are exposed to H2O2. In conclusion, our results indicate that cTPx I is a key component of the antioxidant defense in respiratory-deficient cells. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
dc.description509
dc.description3
dc.description430
dc.description434
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationFebs Letters
dc.relationFEBS Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectthioredoxin peroxidase
dc.subjectoxidative stress
dc.subjectgene expression
dc.subjectmitochondrion
dc.subjectrespiratory deficiency
dc.subjectThiol-specific Antioxidant
dc.subjectOxidative Stress
dc.subjectSaccharomyces-cerevisiae
dc.subjectHydrogen-peroxide
dc.subjectCells
dc.subjectGene
dc.subjectApoptosis
dc.subjectMechanism
dc.subjectResistance
dc.subjectRelease
dc.titleCytosolic thioredoxin peroxidase I is essential for the antioxidant defense of yeast with dysfunctional mitochondria
dc.typeArtículos de revistas


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