dc.creatorBicudo, RCS
dc.creatorSantana, MHA
dc.date2012
dc.dateMAR
dc.date2014-07-30T17:21:40Z
dc.date2015-11-26T17:52:50Z
dc.date2014-07-30T17:21:40Z
dc.date2015-11-26T17:52:50Z
dc.date.accessioned2018-03-29T00:36:22Z
dc.date.available2018-03-29T00:36:22Z
dc.identifierJournal Of Nanoscience And Nanotechnology. Amer Scientific Publishers, v. 12, n. 3, n. 2849, n. 2857, 2012.
dc.identifier1533-4880
dc.identifierWOS:000305039700161
dc.identifier10.1166/jnn.2012.5814
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65037
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65037
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290364
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionHyaluronic acid is a hydrophilic mucopolysaccharide composed of alternating units of D-glucuronic acid and N-acetylglucosamine. It is used in many medical, pharmaceutical, and cosmetic applications, as sponges, films, or particle formulations. Hyaluronic acid nanoparticles can be synthesized free of oil and surfactants by nanoprecipitation in organic solvents, followed by chemical crosslinking. The organic solvent plays an important role in particles size and structure. Therefore, this study aimed to investigate the influence of acetone, ethanol, and isopropyl alcohol on the synthesis and physico-chemical properties of hyaluronic acid nanoparticles. Particles were crosslinked with adipic hydrazide and chloride carbodiimide under controlled conditions. The nanoparticles obtained with all three studied solvents were moderately electrostatically stable. Experiments with acetone produced the smallest particle size (120.44 nm) and polydispersity (0.27). The size and polydispersity of hyaluronic acid nanoparticles correlated with the surface tension between water and the organic solvents, not with the thermodynamic affinity of water for the organic solvents.
dc.description12
dc.description3
dc.description2849
dc.description2857
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherAmer Scientific Publishers
dc.publisherValencia
dc.publisherEUA
dc.relationJournal Of Nanoscience And Nanotechnology
dc.relationJ. Nanosci. Nanotechnol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectHyaluronic Acid
dc.subjectNanotechnology
dc.subjectOil Free Nanoprecipitation
dc.subjectAcetone
dc.subjectIsopropyl Alcohol
dc.subjectEthanol
dc.subjectNanoprecipitation
dc.subjectParameters
dc.titleEffects of Organic Solvents on Hyaluronic Acid Nanoparticles Obtained by Precipitation and Chemical Crosslinking
dc.typeArtículos de revistas


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