F A S N expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

dc.creatorFalci, SGM
dc.creatorMesquita, ATM
dc.creatorde Andrade, BAB
dc.creatorde Miranda, JL
dc.creatorLeon, JE
dc.creatorde Almeida, OP
dc.creatordos Santos, CRR
dc.date2014
dc.dateMAR-APR
dc.date2014-07-30T17:34:20Z
dc.date2015-11-26T17:52:33Z
dc.date2014-07-30T17:34:20Z
dc.date2015-11-26T17:52:33Z
dc.date.accessioned2018-03-29T00:36:04Z
dc.date.available2018-03-29T00:36:04Z
dc.identifierJournal Of Applied Oral Science. Univ Sao Paulo Fac Odontologia Bauru, v. 22, n. 2, n. 131, n. 137, 2014.
dc.identifier1678-7757
dc.identifier1678-7765
dc.identifierWOS:000333666100010
dc.identifier10.1590/1678-7757201130509
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66625
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66625
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290286
dc.descriptionCentral giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.
dc.description22
dc.description2
dc.description131
dc.description137
dc.descriptionUniversity of Vales do Jequitinhonha e Mucuri
dc.languageen
dc.publisherUniv Sao Paulo Fac Odontologia Bauru
dc.publisherBauru-sp
dc.publisherBrasil
dc.relationJournal Of Applied Oral Science
dc.relationJ. Appl. Oral Sci.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectGiant cell lesion
dc.subjectImmunohistochemistry
dc.subjectAngiogenesis
dc.subjectLymphangiogenesis
dc.subjectFatty acid synthase
dc.subjectFatty-acid Synthase
dc.subjectImmunohistochemical Evaluation
dc.subjectGrowth-factor
dc.subjectJaws
dc.subjectVascularity
dc.subjectInhibition
dc.subjectOrlistat
dc.subjectBehavior
dc.subjectCancer
dc.subjectTumors
dc.titleF A S N expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions
dc.typeArtículos de revistas


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