THE DEVELOPMENT OF HUMORAL IMMUNOLOGICAL MEMORY TO A T-CELL-DEPENDENT ANTIGEN REQUIRES THYMIC EMIGRANT CELLS

dc.creatorDEALBUQUERQUE, DA
dc.creatorAROEIRA, LS
dc.creatorWILLIAMS, O
dc.creatorMENGEL, J
dc.date1994
dc.dateMAR-APR
dc.date2014-12-16T11:32:44Z
dc.date2015-11-26T17:51:37Z
dc.date2014-12-16T11:32:44Z
dc.date2015-11-26T17:51:37Z
dc.date.accessioned2018-03-29T00:35:01Z
dc.date.available2018-03-29T00:35:01Z
dc.identifierResearch In Immunology. Editions Scientifiques Elsevier, v. 145, n. 3, n. 185, n. 195, 1994.
dc.identifier0923-2494
dc.identifierWOS:A1994PB86300002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74911
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/74911
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74911
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290023
dc.descriptionImmunological memory is embodied in the rapid and enhanced immune responsiveness to previously encountered antigens. Classically, memory would depend on the presence of small resting long-lived specific lymphocytes which, through clonal expansion after priming with antigen, would be present at higher frequencies than in naive animals. Here we report that T-cell-reconstituted athymic mice, which lack recent thymic emigrants, mount a primary response to a T-cell-dependent antigen, but do not develop memory or the capacity to produce specific anti-TNP IgG1 antibodies during the secondary immune response. On the other hand, if thymocytes are continuously provided during the secondary response, a typical secondary immune response is achieved with high levels of specific IgG1. These results lead us to propose that the development of humoral immunological memory cannot be explained solely by the long life span of primed T lymphocytes, but is rather a dynamic state dependent on the continuous presence of recent thymic emigrants and qualitative functional differences in responder T cells.
dc.description145
dc.description3
dc.description185
dc.description195
dc.languageen
dc.publisherEditions Scientifiques Elsevier
dc.publisherParis Cedex 15
dc.publisherFrança
dc.relationResearch In Immunology
dc.relationRes. Immunol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectT LYMPHOCYTE
dc.subjectTHYMUS
dc.subjectIMMUNOLOGICAL MEMORY
dc.subjectIGG1
dc.subjectDYNAMIC STATE
dc.subjectTHYMIC EMIGRANTS
dc.subjectMOUSE
dc.subjectMonoclonal-antibody
dc.subjectFunctional-heterogeneity
dc.subjectStimulatory Factor
dc.subjectB-cells
dc.subjectInvivo
dc.subjectCd4+
dc.subjectResponses
dc.subjectMouse
dc.subjectInterleukin-4
dc.subjectLymphocytes
dc.titleTHE DEVELOPMENT OF HUMORAL IMMUNOLOGICAL MEMORY TO A T-CELL-DEPENDENT ANTIGEN REQUIRES THYMIC EMIGRANT CELLS
dc.typeArtículos de revistas


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