Brasil | Artículos de revistas

Vero cell growth and differentiation on poly(L-lactic acid) membranes of different pore diameters

dc.creatorSantos, AR
dc.creatorBarbanti, SH
dc.creatorDuek, EAR
dc.creatorDolder, H
dc.creatorWada, RS
dc.creatorWada, MLF
dc.date2001
dc.dateJAN
dc.date2014-11-18T15:33:00Z
dc.date2015-11-26T17:51:33Z
dc.date2014-11-18T15:33:00Z
dc.date2015-11-26T17:51:33Z
dc.date.accessioned2018-03-29T00:34:57Z
dc.date.available2018-03-29T00:34:57Z
dc.identifierArtificial Organs. Blackwell Science Inc, v. 25, n. 1, n. 7, n. 13, 2001.
dc.identifier0160-564X
dc.identifierWOS:000166800300002
dc.identifier10.1046/j.1525-1594.2001.025001007.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/72724
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/72724
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/72724
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290002
dc.descriptionIn the last few years, the demand has increased for research on polymeric materials, which can be used as substitutes for injured tissues and organs or to improve their regeneration. In this work, we studied poly(L-lactic acid) (PLLA) membranes, a resorbable biomaterial, which were either dense or had different pore diameters (less than 45 mum, between 180 and 250 mum, and between 250 and 350 mum), in relation to stimulation of cell adhesion, growth, and differentiation in vitro. We used Vero cells, a fibroblastic cell line, as the biological model of investigation. We found that cells attached slowly to all PLLA membranes studied. On the Ether hand, once the adhesion occurs, the cells are able to grow and differentiate on the different polymers. The cells grew to form a confluent monolayer and were capable of producing collagen Type IV and fibronectin on different PLLA membranes. This behavior indicates that cells try to create a better environment to stimulate their growth. This also indicates that Vero cells alter their differentiation pattern once they are producing extracellular matrix molecules related to epithelial differentiation.
dc.description25
dc.description1
dc.description7
dc.description13
dc.languageen
dc.publisherBlackwell Science Inc
dc.publisherMalden
dc.publisherEUA
dc.relationArtificial Organs
dc.relationArtif. Organs
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectbiomaterials
dc.subjectcell culture
dc.subjectcell adhesion
dc.subjectcell growth
dc.subjectcell differentiation
dc.subjectpoly(L-lactic acid)
dc.subjectBiodegradable Polymer Scaffolds
dc.subjectBone-formation
dc.subjectAdhesion
dc.subjectCulture
dc.subjectMatrix
dc.subjectBiocompatibility
dc.subjectSurfaces
dc.subjectCollagen
dc.subjectAssay
dc.titleVero cell growth and differentiation on poly(L-lactic acid) membranes of different pore diameters
dc.typeArtículos de revistas


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