dc.creator | Carvalho, VH | |
dc.creator | Braga, ADD | |
dc.creator | Braga, FSD | |
dc.creator | Loyola, YCS | |
dc.creator | de Araujo, DR | |
dc.creator | Mantovani, M | |
dc.date | 2009 | |
dc.date | MAY-JUN | |
dc.date | 2014-07-30T19:38:20Z | |
dc.date | 2015-11-26T17:51:24Z | |
dc.date | 2014-07-30T19:38:20Z | |
dc.date | 2015-11-26T17:51:24Z | |
dc.date.accessioned | 2018-03-29T00:34:47Z | |
dc.date.available | 2018-03-29T00:34:47Z | |
dc.identifier | Acta Cirurgica Brasileira. Acta Cirurgica Brasileira, v. 24, n. 3, n. 211, n. 215, 2009. | |
dc.identifier | 0102-8650 | |
dc.identifier | WOS:000266785400009 | |
dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73485 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/73485 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1289967 | |
dc.description | Purpose: To evaluate in vitro lidocaine and racemic bupivacaine effects in neuromuscular transmission and in neuromuscular blockade produced by rocuronium. Methods: Rats were distributed in 5 groups (n = 5) in agreement with the studied drugs: lidocaine, racemic bupivacaine, rocuronium, separately (Groups I, II, III); rocuronium in preparations exposed to local anesthetics (Groups IV, V). The concentrations used were: 20 mu g/mL, 5 mu g/mL and 4 mu g/mL, for lidocaine, bupivacaine and rocuronium, respectively. It was evaluated: 1) amplitude of diaphragm muscle response to indirect stimulation, before and 60 minutes after separately addition of lidocaine, racemic bupivacaine and rocuronium and the association of local anesthetics-rocuronium; 2) membrane potentials (MP) and miniature end-plate potentials (MEPP). Results: Lidocaine and bupivacaine separately didn't alter the amplitude of muscle response and MP. In preparations previously exposed to lidocaine and racemic bupivacaine, the rocuronium blockade was significantly larger (90.10 +/- 9.15% and 100%, respectively), in relation to the produced by rocuronium separately (73.12 +/- 9.89%). Lidocaine caused an increase in the frequency of MEPP, being followed by blockade; racemic bupivacaine produced decrease being followed by blockade. Conclusions: Local anesthetics potentiated the blockade caused by rocuronium. The alterations of MEPP identify presynaptic action. | |
dc.description | 24 | |
dc.description | 3 | |
dc.description | 211 | |
dc.description | 215 | |
dc.language | en | |
dc.publisher | Acta Cirurgica Brasileira | |
dc.publisher | Sao Paulo | |
dc.publisher | Brasil | |
dc.relation | Acta Cirurgica Brasileira | |
dc.relation | Acta Cir. Bras. | |
dc.rights | aberto | |
dc.source | Web of Science | |
dc.subject | Anesthetics, Local | |
dc.subject | Lidocaine | |
dc.subject | Bupivacaine | |
dc.subject | Neuromuscular Blocking Agents | |
dc.subject | Rats | |
dc.subject | Local-anesthetics | |
dc.subject | Acetylcholine-receptor | |
dc.subject | Drug-interactions | |
dc.subject | Muscle-relaxants | |
dc.subject | Junction | |
dc.subject | Mepivacaine | |
dc.subject | Channels | |
dc.title | The influence of lidocaine and racemic bupivacaine on neuromuscular blockade produced by rocuronium. A study in rat phrenic nerve-diaphragm preparation | |
dc.type | Artículos de revistas | |