The influence of lidocaine and racemic bupivacaine on neuromuscular blockade produced by rocuronium. A study in rat phrenic nerve-diaphragm preparation

dc.creatorCarvalho, VH
dc.creatorBraga, ADD
dc.creatorBraga, FSD
dc.creatorLoyola, YCS
dc.creatorde Araujo, DR
dc.creatorMantovani, M
dc.date2009
dc.dateMAY-JUN
dc.date2014-07-30T19:38:20Z
dc.date2015-11-26T17:51:24Z
dc.date2014-07-30T19:38:20Z
dc.date2015-11-26T17:51:24Z
dc.date.accessioned2018-03-29T00:34:47Z
dc.date.available2018-03-29T00:34:47Z
dc.identifierActa Cirurgica Brasileira. Acta Cirurgica Brasileira, v. 24, n. 3, n. 211, n. 215, 2009.
dc.identifier0102-8650
dc.identifierWOS:000266785400009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73485
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73485
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289967
dc.descriptionPurpose: To evaluate in vitro lidocaine and racemic bupivacaine effects in neuromuscular transmission and in neuromuscular blockade produced by rocuronium. Methods: Rats were distributed in 5 groups (n = 5) in agreement with the studied drugs: lidocaine, racemic bupivacaine, rocuronium, separately (Groups I, II, III); rocuronium in preparations exposed to local anesthetics (Groups IV, V). The concentrations used were: 20 mu g/mL, 5 mu g/mL and 4 mu g/mL, for lidocaine, bupivacaine and rocuronium, respectively. It was evaluated: 1) amplitude of diaphragm muscle response to indirect stimulation, before and 60 minutes after separately addition of lidocaine, racemic bupivacaine and rocuronium and the association of local anesthetics-rocuronium; 2) membrane potentials (MP) and miniature end-plate potentials (MEPP). Results: Lidocaine and bupivacaine separately didn't alter the amplitude of muscle response and MP. In preparations previously exposed to lidocaine and racemic bupivacaine, the rocuronium blockade was significantly larger (90.10 +/- 9.15% and 100%, respectively), in relation to the produced by rocuronium separately (73.12 +/- 9.89%). Lidocaine caused an increase in the frequency of MEPP, being followed by blockade; racemic bupivacaine produced decrease being followed by blockade. Conclusions: Local anesthetics potentiated the blockade caused by rocuronium. The alterations of MEPP identify presynaptic action.
dc.description24
dc.description3
dc.description211
dc.description215
dc.languageen
dc.publisherActa Cirurgica Brasileira
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationActa Cirurgica Brasileira
dc.relationActa Cir. Bras.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectAnesthetics, Local
dc.subjectLidocaine
dc.subjectBupivacaine
dc.subjectNeuromuscular Blocking Agents
dc.subjectRats
dc.subjectLocal-anesthetics
dc.subjectAcetylcholine-receptor
dc.subjectDrug-interactions
dc.subjectMuscle-relaxants
dc.subjectJunction
dc.subjectMepivacaine
dc.subjectChannels
dc.titleThe influence of lidocaine and racemic bupivacaine on neuromuscular blockade produced by rocuronium. A study in rat phrenic nerve-diaphragm preparation
dc.typeArtículos de revistas


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