The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models

dc.creatorBrito, MV
dc.creatorde Oliveira, C
dc.creatorSalu, BR
dc.creatorAndrade, SA
dc.creatorMalloy, PMD
dc.creatorSato, AC
dc.creatorVicente, CP
dc.creatorSampaio, MU
dc.creatorMaffei, FHA
dc.creatorOliva, MLV
dc.date2014
dc.dateMAY
dc.date2014-07-30T19:38:32Z
dc.date2015-11-26T17:51:20Z
dc.date2014-07-30T19:38:32Z
dc.date2015-11-26T17:51:20Z
dc.date.accessioned2018-03-29T00:34:44Z
dc.date.available2018-03-29T00:34:44Z
dc.identifierThrombosis Research. Pergamon-elsevier Science Ltd, v. 133, n. 5, n. 945, n. 951, 2014.
dc.identifier0049-3848
dc.identifierWOS:000334739100038
dc.identifier10.1016/j.thromres.2014.02.027
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73580
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73580
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289956
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (Kiapp 2.4 nmol/L and 5.2 nmol/L, respectively). This inhibitory activity is possibly responsible for an effect on hemostasis by prolonging activated partial thromboplastin time (aPTT). Because the association between cancer and thrombosis is well established, we evaluated the possible antithrombotic activity of this protein in venous and arterial thrombosis models. Vein thrombosis was studied in the vena cava ligature model in Wistar rats, and arterial thrombosis in the photochemical induced endothelium lesion model in the carotid artery of C57 black 6 mice. BbKI at a concentration of 2.0 mg/kg reduced the venous thrombus weight by 65% in treated rats in comparison to rats in the control group. The inhibitor prolonged the time for total artery occlusion in the carotid artery model mice indicating that this potent plasma kallikrein inhibitor prevented thrombosis. (C) 2014 Elsevier Ltd. All rights reserved.
dc.description133
dc.description5
dc.description945
dc.description951
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2009/53766-5, 2012/23640-2]
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationThrombosis Research
dc.relationThromb. Res.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBlood coagulation
dc.subjectKallikrein
dc.subjectKunitz inhibitor
dc.subjectThrombosis
dc.subjectTrypsin inhibitor
dc.subjectTumor cells
dc.subjectKunitz Proteinase-inhibitors
dc.subjectProstate-specific Antigen
dc.subjectHuman Plasma Kallikrein
dc.subjectReactive-site Sequence
dc.subjectSynthetic Peptides
dc.subjectCell-lines
dc.subjectCancer
dc.subjectActivation
dc.subjectSystem
dc.subjectSeeds
dc.titleThe Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models
dc.typeArtículos de revistas


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