UVB: susceptibility as a risk factor to the development of lepromatous leprosy

dc.creatorRodrigues, MM
dc.creatorXimenes, RAD
dc.creatorDantas, MMD
dc.creatorBatista, TD
dc.creatorFreire, AD
dc.date2010
dc.dateNOV-DEC
dc.date2014-07-30T19:07:36Z
dc.date2015-11-26T17:50:49Z
dc.date2014-07-30T19:07:36Z
dc.date2015-11-26T17:50:49Z
dc.date.accessioned2018-03-29T00:34:08Z
dc.date.available2018-03-29T00:34:08Z
dc.identifierAnais Brasileiros De Dermatologia. Soc Brasileira Dermatologia, v. 85, n. 6, n. 839, n. 842, 2010.
dc.identifier0365-0596
dc.identifierWOS:000287147000009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73098
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73098
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289802
dc.descriptionBACKGROUNDS - Ultraviolet radiation B (UVRB) is the most important environmental factor capable of altering the immune function of human skin. OBJECTIVE: To evaluate the association of the phenotypes of susceptibility or resistance to ultraviolet radiation B (UVRB) and the polar forms of leprosy. MATERIAL AND METHODS: We evaluated 38 patients with lepromatous leprosy (LL) and 87 patients with tuberculoid (TT) leprosy, according to the classification by Ridley and Jopling (1966). All the patients were submitted to a test to determine the phenotypes of susceptibility or resistance to UVRB through the application of a 2% dinitrochlorobenzene (DNCB) disc to a previously irradiated area with twice the minimal erythema dose (MED). After 21 days, a similar disc soaked in 0.05% DNCB was applied to the scapular area (unexposed to UVRB) to check for sensitiveness, with reading of the results after 48 hours. The patients that showed a positive reaction to DNCB were considered resistant (UVB-R) and those who did not show any reaction were considered susceptible (UVB-S). RESULTS: The frequency of UVB-S individuals was 63.2% (24 patients) in the LL group and 34.4% (30 patients) in the TT group (OR=3.26; IC=1.36 - 7.87; x(2)=7.73; p=0.005). CONCLUSION: Our results suggest that UVB-susceptibility is a risk factor to the development of lepromatous leprosy (LL).
dc.description85
dc.description6
dc.description839
dc.description842
dc.languageen
dc.publisherSoc Brasileira Dermatologia
dc.publisherRio De Janeiro Rj
dc.publisherBrasil
dc.relationAnais Brasileiros De Dermatologia
dc.relationAn. Brasil. Dermatol.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectLeprosy
dc.subjectLeprosy
dc.subjectlepromatous
dc.subjectPhotobiology
dc.subjectEpidermal Langerhans Cells
dc.subjectNecrosis-factor-alpha
dc.subjectUltraviolet-light-b
dc.subjectMycobacterium-leprae
dc.subjectImmune-response
dc.titleUVB: susceptibility as a risk factor to the development of lepromatous leprosy
dc.typeArtículos de revistas


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