Verrucous carcinoma of the penis, also known as Buschke-Lowenstein tumor or giant malignant condyloma, is a low grade cancer of well differentiated squamous cells. It is probably caused by the human papillomavirus, which grows slowly and compresses adjacent structures but does not have a tendency to metastasize. The transformation into squamous cell carcinoma is still speculative. The tumor has been reported in men 18 to 86 years old. Conventional surgery is the traditional treatment and permits histopathological evaluation of the surgical specimen. Surgery ranges from circumcision to total amputation. Recurrence has been reported even after conventional exeresis.(1) Cryosurgery as a therapeutic option has shown good results, with remission rates comparable to those of conventional surgery for treating general malignant lesions.(2,3) Malignant cells are more susceptible to cryonecrosis and, in fact, liquid nitrogen is the best substance to use in cryosurgery because it is easier to apply, achieves low temperatures in the tissues and is able to destroy a great volume of tissue.168310961097