Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District

dc.creatorMesquita, DR
dc.creatorCordoba, JC
dc.creatorMagalhaes, IQ
dc.creatorCordoba, MS
dc.creatorOliveira, JRC
dc.creatorGoncalves, A
dc.creatorFerrari, I
dc.creatorMartins-de-Sa, C
dc.date2009
dc.date2014-11-18T12:36:50Z
dc.date2015-11-26T17:50:18Z
dc.date2014-11-18T12:36:50Z
dc.date2015-11-26T17:50:18Z
dc.date.accessioned2018-03-29T00:33:30Z
dc.date.available2018-03-29T00:33:30Z
dc.identifierGenetics And Molecular Research. Funpec-editora, v. 8, n. 1, n. 345, n. 353, 2009.
dc.identifier1676-5680
dc.identifierWOS:000265578600035
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57719
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57719
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57719
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289640
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAcute lymphoblastic leukemia (ALL) accounts for approximately 80% of all acute leukemias during childhood. Chromosomal anomalies resulting from gene fusion, which are frequent in leukemias, create hybrid transcripts, the great majority of which encode transcription factors. We analyzed 88 pediatric patients (median age 7.3 years) who had B-lineage acute lymphoblastic leukemia (B-ALL), using reverse transcriptase-polymerase chain reaction, to look for gene fusion transcripts of TEL/AML1, E2A/PBX1, BCR/ABL p190, and MLL/AF4. The frequencies of these transcripts were 21.21, 9.68, 3.03, and 0%, respectively. All positive cases had a common B-ALL immunophenotype. The low frequency of the TEL/AML1 transcript that is found in developing countries, such as Brazil, may be due to the low incidence of leukemia; this would support Greaves' hypothesis.
dc.description8
dc.description1
dc.description345
dc.description353
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPEAM
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [380/4]
dc.languageen
dc.publisherFunpec-editora
dc.publisherRibeirao Preto
dc.publisherBrasil
dc.relationGenetics And Molecular Research
dc.relationGenet. Mol. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectAcute lymphoblastic leukemia
dc.subjectCytogenetics
dc.subjectReverse transcriptase-polymerase chain reaction
dc.subjectChromosomal anomalies
dc.subjectHybrid transcripts
dc.subjectAcute Myeloid-leukemia
dc.subjectFusion Gene
dc.subjectWhite-children
dc.subjectBcr-abl
dc.subjectChildhood
dc.subjectRearrangements
dc.subjectTel/aml1
dc.subjectTranslocations
dc.subjectAbnormalities
dc.subjectTranscripts
dc.titleMolecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución