PERIPHERAL-NERVE REPAIR USING A POLY(ORGANO)PHOSPHAZENE TUBULAR PROSTHESIS

dc.creatorLANGONE, F
dc.creatorLORA, S
dc.creatorVERONESE, FM
dc.creatorCALICETI, P
dc.creatorPARNIGOTTO, PP
dc.creatorVALENTI, F
dc.creatorPALMA, G
dc.date1995
dc.dateMAR
dc.date2014-12-16T11:32:00Z
dc.date2015-11-26T17:50:17Z
dc.date2014-12-16T11:32:00Z
dc.date2015-11-26T17:50:17Z
dc.date.accessioned2018-03-29T00:33:29Z
dc.date.available2018-03-29T00:33:29Z
dc.identifierBiomaterials. Elsevier Sci Ltd, v. 16, n. 5, n. 347, n. 353, 1995.
dc.identifier0142-9612
dc.identifierWOS:A1995QM97800001
dc.identifier10.1016/0142-9612(95)93851-4
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59341
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/59341
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59341
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289636
dc.descriptionNerve regeneration experiments were carried out using tubular nerve guides of poly[(ethylalanato)(1.4)(imidazolyl)(0.6)phosphazene] (PEIP). By means of in vivo tests, this polymer was found to be biodegradable and transformed into harmless products. The tubular nerve guides were prepared by deposition of the dissolved polymer on a glass capillary tube, followed by evaporation of the solvent (methylene dichloride). After transectioning, rat sciatic nerve stumps were immediately sutured into the ends of 10-mm-long polymer tubes. On removal bf the prosthesis, after implantation for 45 d, a tissue cable was found bridging the nerve stumps in all cases. Histological analysis revealed that the tissue cable was essentially composed of a regenerated nerve fibre bundle. A parallel series of experiments was undertaken to compare the use of silicone tubes that are not biodegradable and are most frequently used for studies of nerve regeneration with tubulization techniques, The advantages of biodegradable PEIP tubular nerve guides used for peripheral nerve repair are discussed.
dc.description16
dc.description5
dc.description347
dc.description353
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationBiomaterials
dc.relationBiomaterials
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectPOLYPHOSPHAZENE
dc.subjectBIODEGRADATION
dc.subjectTUBULAR PROSTHESIS
dc.subjectPERIPHERAL NERVE REPAIR
dc.subjectNERVE REGENERATION
dc.subjectSilicone Tube Splices
dc.subjectMouse Sciatic-nerve
dc.subjectMesothelial Chambers
dc.subjectGuidance Channels
dc.subjectPolyglactin Tube
dc.subjectAxonal Growth
dc.subjectRegeneration
dc.subjectLaminin
dc.subjectFibers
dc.subjectMatrix
dc.titlePERIPHERAL-NERVE REPAIR USING A POLY(ORGANO)PHOSPHAZENE TUBULAR PROSTHESIS
dc.typeArtículos de revistas


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