Modulation of the severity of experimental autoimmune encephalomyelitis by gamma delta T lymphocytes activated by mycobacterial antigens

dc.creatorDiaz-Bardales, BM
dc.creatorNovaski, SMS
dc.creatorGoes, AE
dc.creatorCastro, GM
dc.creatorMengel, J
dc.creatorSantos, LMB
dc.date2001
dc.date2014-11-18T12:22:55Z
dc.date2015-11-26T17:50:13Z
dc.date2014-11-18T12:22:55Z
dc.date2015-11-26T17:50:13Z
dc.date.accessioned2018-03-29T00:33:24Z
dc.date.available2018-03-29T00:33:24Z
dc.identifierImmunological Investigations. Marcel Dekker Inc, v. 30, n. 3, n. 245, n. 258, 2001.
dc.identifier0882-0139
dc.identifierWOS:000170983200007
dc.identifier10.1081/IMM-100105068
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57703
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57703
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57703
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289617
dc.descriptionImmunity to mycobacterial antigens may contribute to the maintenance of self-tolerance. Exposure of the immune system to mycobacterial antigen might well stimulate the immune system to exert control over unwanted self-reactive clones. We demonstrated that in vivo administration of Mycobacterium tuberculosis, PPD, and PPD peptide (180-196) prior to immunization with Myelin Basic Protein (MBP) led to a moderate increase of gamma delta T cells, suppression of the immune response, and reduction in the severity of Experimental Autoimmune Encephalomyelitis. The immunosuppression observed is due, at least in part, to the production of Transforming growth factor-beta (TGF beta) by the gamma delta T lymphocytes.
dc.description30
dc.description3
dc.description245
dc.description258
dc.languageen
dc.publisherMarcel Dekker Inc
dc.publisherNew York
dc.publisherEUA
dc.relationImmunological Investigations
dc.relationImmunol. Invest.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectEAE
dc.subjectautoimmunity
dc.subjectTGF beta
dc.subjectT TCR gamma delta
dc.subjectmycobacterial antigens
dc.subjectExperimental Allergic Encephalomyelitis
dc.subjectTransforming Growth Factor-beta-1
dc.subjectCell Receptor
dc.subjectOral Tolerance
dc.subjectAdjuvant Arthritis
dc.subjectMultiple-sclerosis
dc.subjectProtein
dc.subjectMice
dc.subjectRat
dc.subjectTuberculosis
dc.titleModulation of the severity of experimental autoimmune encephalomyelitis by gamma delta T lymphocytes activated by mycobacterial antigens
dc.typeArtículos de revistas


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