Neuroimaging changes in mesial temporal lobe epilepsy are magnified in the presence of depression

dc.creatorSalgado, PCB
dc.creatorYasuda, CL
dc.creatorCendes, F
dc.date2010
dc.dateNOV
dc.date2014-11-18T11:38:24Z
dc.date2015-11-26T17:49:56Z
dc.date2014-11-18T11:38:24Z
dc.date2015-11-26T17:49:56Z
dc.date.accessioned2018-03-29T00:33:04Z
dc.date.available2018-03-29T00:33:04Z
dc.identifierEpilepsy & Behavior. Academic Press Inc Elsevier Science, v. 19, n. 3, n. 422, n. 427, 2010.
dc.identifier1525-5050
dc.identifierWOS:000285451600038
dc.identifier10.1016/j.yebeh.2010.08.012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65279
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/65279
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65279
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289527
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionObjective: The aim of this study was to investigate differences in gray matter volume between patients with mesial temporal lobe epilepsy (MTLE) with and without depression using voxel-based morphometry. Method: We included 48 adults with refractory MTLE (31 women, 39.18 +/- 8.4 years) and 96 healthy controls (75 women, 37.11 +/- 8.9 years). For the psychiatric evaluation, the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Axis I, was used for the diagnosis of depression, and the Beck Depression Inventory, for the determination of symptom intensity. All patients underwent an MRI scan. Patients were separated into two groups: those with MTLE with depression (n = 24) and those with MILE without depression (n=24). We performed voxel-based morphometric analysis, comparing patients with controls using the t test. Results: The number of areas of gray matter volume loss was higher in patients with MTLE with depression than in those with MTLE without depression. Conclusions: The evidence of more widespread gray matter volume loss in patients with MTLE and depression calls our attention to the importance of timely recognition and treatment of depression in patients with MTLE and also to the bidirectional relationship between the two disorders and their frequent co-occurrence. (C) 2010 Elsevier Inc. All rights reserved.
dc.description19
dc.description3
dc.description422
dc.description427
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [05/56578-4, 07/51280-2]
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationEpilepsy & Behavior
dc.relationEpilepsy Behav.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectDysthymic disorder
dc.subjectDepression
dc.subjectMesial temporal lobe epilepsy
dc.subjectAtrophy
dc.subjectMagnetic resonance imaging
dc.subjectVoxel-based morphometry
dc.subjectMajor Depression
dc.subjectHippocampal Volume
dc.subjectSeizures
dc.subjectCortex
dc.subjectRisk
dc.subjectDisorders
dc.subjectReduction
dc.subjectInventory
dc.subjectAnxiety
dc.subjectPeople
dc.titleNeuroimaging changes in mesial temporal lobe epilepsy are magnified in the presence of depression
dc.typeArtículos de revistas


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