Cutaneous Metastasis From a Classic Papillary Thyroid Cancer With Positive Immunohistochemical Staining for Sodium Iodide Symporter but No Response to Radioiodine Therapy

dc.creatorWard, LS
dc.creatorRezende, CAC
dc.creatorMorari, EC
dc.creatorCamacho, E
dc.creatorVassallo, J
dc.date2009
dc.dateSEP-OCT
dc.date2014-11-18T11:11:33Z
dc.date2015-11-26T17:49:50Z
dc.date2014-11-18T11:11:33Z
dc.date2015-11-26T17:49:50Z
dc.date.accessioned2018-03-29T00:32:56Z
dc.date.available2018-03-29T00:32:56Z
dc.identifierEndocrinologist. Lippincott Williams & Wilkins, v. 19, n. 5, n. 214, n. 217, 2009.
dc.identifier1051-2144
dc.identifierWOS:000270014300005
dc.identifier10.1097/TEN.0b013e3181b5aa91
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57526
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57526
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57526
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289494
dc.descriptionA 76-year-old man presented with small reddish, painless nodular lesions of the chest and on neck surgical scars. The patient had, 5 years before, a T3N1M0 classic papillary thyroid carcinoma that evolved with recurrent cervical lymph node metastasis despite 3 surgeries and a cumulative dose of 500 mCi of (131)Iodine. Investigations included the lesion biopsy and Tg immunohistochemistry, which led to the diagnosis of rare skin metastasis from a well differentiated thyroid tumor. The cutaneous lesions also tested positive for sodium iodide symporter protein, with clear membrane immunohistochemical staining. However, the patient did not respond to an additional dose of 400 mCi of radioiodine, suggesting a nonfunctional sodium iodide symporter protein. The lesions rapidly spread to the chest wall and erythematous red-purple inflamed nodules became confluent over a 3-month period. The tumor invaded the trachea causing the patient's death.
dc.description19
dc.description5
dc.description214
dc.description217
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationEndocrinologist
dc.relationEndocrinologist
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectdifferentiated thyroid carcinoma
dc.subjectskin
dc.subjectmetastasis
dc.subjectmolecular markers
dc.subjectimmunohistochemistry
dc.subjectOf-the-literature
dc.subjectFollow-up
dc.subjectCarcinoma
dc.subjectSkin
dc.subjectExpression
dc.subjectManagement
dc.subjectMetabolism
dc.subjectImpact
dc.titleCutaneous Metastasis From a Classic Papillary Thyroid Cancer With Positive Immunohistochemical Staining for Sodium Iodide Symporter but No Response to Radioiodine Therapy
dc.typeArtículos de revistas


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