Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission

dc.creatorBrandao, CO
dc.creatorRuocco, HH
dc.creatorFarias, AD
dc.creatorOliveira, C
dc.creatorHallal-Longo, DEM
dc.creatorMirandola, SR
dc.creatorOliveira, EC
dc.creatorCendes, F
dc.creatorDamasceno, BP
dc.creatorSantos, LMB
dc.date2005
dc.dateDEC
dc.date2014-11-18T10:26:50Z
dc.date2015-11-26T17:49:20Z
dc.date2014-11-18T10:26:50Z
dc.date2015-11-26T17:49:20Z
dc.date.accessioned2018-03-29T00:32:22Z
dc.date.available2018-03-29T00:32:22Z
dc.identifierArquivos De Neuro-psiquiatria. Assoc Arquivos De Neuro- Psiquiatria, v. 63, n. 4, n. 914, n. 919, 2005.
dc.identifier0004-282X
dc.identifierWOS:000233987900002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57599
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57599
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57599
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289348
dc.descriptionCytokines and intrathecal IgG synthesis were determined in the cerebrospina fluid (CSF) and sera to evaluate inflammatory activity in multiple sclerosis (MS) patients during clinical remission. Although the disease was stable, there had been a significant increase of proinflammatory cytokines such as TNF alpha and IFN gamma in the CSF and serum, with no significant changes of IL12 and IL10 production. The changes in the cytokine production patterns were associated with an increase of leukocytes in the CSF, as well as the presence of oligoclonal bands suggesting intrathecal IgG synthesis. These results suggest that even when the disease is clinically silent, one can observe inflammatory activity in these MS patients.
dc.description63
dc.description4
dc.description914
dc.description919
dc.languageen
dc.publisherAssoc Arquivos De Neuro- Psiquiatria
dc.publisherSao Paulo Sp
dc.publisherBrasil
dc.relationArquivos De Neuro-psiquiatria
dc.relationArq. Neuro-Psiquiatr.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectmultiple sclerosis
dc.subjectcerebrospinal fluid
dc.subjectcytokines
dc.subjectintrathecal IgG synthesis
dc.subjectCentral-nervous-system
dc.subjectNecrosis-factor-alpha
dc.subjectCerebrospinal-fluid
dc.subjectTnf-alpha
dc.subjectMessenger-rna
dc.subjectSerum-levels
dc.subjectIfn-gamma
dc.subjectInterleukin-10
dc.subjectMyelin
dc.subjectAssociation
dc.titleCytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
dc.typeArtículos de revistas


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