Cytokine gene expression in Walker 256: A comparison of variants A (aggressive) and AR (regressive)

dc.creatorPerroud, APDS
dc.creatorAshimine, R
dc.creatorDe Castro, GM
dc.creatorGuimaraes, F
dc.creatorVieira, KP
dc.creatorVilella, CA
dc.creatorCavalcanti, TCS
dc.creatorZollner, RD
dc.date2006
dc.dateNOV
dc.date2014-11-18T10:22:49Z
dc.date2015-11-26T17:49:20Z
dc.date2014-11-18T10:22:49Z
dc.date2015-11-26T17:49:20Z
dc.date.accessioned2018-03-29T00:32:22Z
dc.date.available2018-03-29T00:32:22Z
dc.identifierCytokine. Academic Press Ltd Elsevier Science Ltd, v. 36, n. 41732, n. 123, n. 133, 2006.
dc.identifier1043-4666
dc.identifierWOS:000245155900004
dc.identifier10.1016/j.cyto.2006.11.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57597
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57597
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57597
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289347
dc.descriptionTwo variants of this Walker 256 tumor have been previously reported as Walker 256 A and variant AR. The variant A has more aggressive property than variant AR and can induce systemic effects such as anorexia, sodium and water retention, followed by weight loss and death. The mechanisms involved in enhancing tumor regression and progression in this model are still incompletely understood. In the present study, serum and spleen mononuclear cells and tumor cells from animals inoculated with variants A and AR, were isolated to investigate the TGF-beta, IL-12, IFN-gamma and TNF-alpha and relationship with anemia, weight of animals, weight of spleen, volume of tumor and osmotic fragility compared with controls inoculated with Ringer Lactate. Results demonstrate that the group inoculated with variant A, compared to variant AR, shows high levels of TGF-beta gene expression in both tumor tissue and spleen cells, no expression of IFN-gamma and a progressive and higher levels of IL-12 in tumor tissue without inflammatory infiltrate visualized by optical microscopy. These results suggest that the aggressively of variant A is relate to cytokine modulation, facilitating the growth and escape of tumor cells. Furthermore, IL-12 seems to be constitutively expressed in both tumor lineage A and A R. (c) 2006 Elsevier Ltd. All rights reserved.
dc.description36
dc.description41732
dc.description123
dc.description133
dc.languageen
dc.publisherAcademic Press Ltd Elsevier Science Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationCytokine
dc.relationCytokine
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectWalker 256
dc.subjectcytokines
dc.subjectimmunomodulation
dc.subjectTransforming Growth-factor-beta-1 Transgene
dc.subjectInterferon-gamma
dc.subjectChronic Disease
dc.subjectTumor
dc.subjectInterleukin-12
dc.subjectAnemia
dc.subjectAlpha
dc.subjectCells
dc.subjectPathogenesis
dc.subjectSuppression
dc.titleCytokine gene expression in Walker 256: A comparison of variants A (aggressive) and AR (regressive)
dc.typeArtículos de revistas


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