Role of acetylcholine in electrical stimulation-induced arrhythmia in rat isolated atria

dc.creatorGodoy, CMG
dc.creatorBassani, RA
dc.creatorBassani, JWM
dc.date1999
dc.dateOCT
dc.date2014-07-30T18:28:13Z
dc.date2015-11-26T17:49:00Z
dc.date2014-07-30T18:28:13Z
dc.date2015-11-26T17:49:00Z
dc.date.accessioned2018-03-29T00:32:02Z
dc.date.available2018-03-29T00:32:02Z
dc.identifierJournal Of Cardiovascular Pharmacology. Lippincott Williams & Wilkins, v. 34, n. 4, n. 475, n. 479, 1999.
dc.identifier0160-2446
dc.identifierWOS:000082640400001
dc.identifier10.1097/00005344-199910000-00001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71204
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71204
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289279
dc.descriptionIn this study, we used the spontaneously beating, isolated rat right atrium as an in vitro model to study arrhythmogenic effects of electrical stimulation. A tetrapolar platinum electrode was used for stimulation and recording of atrial electrical activity at 36.5 degrees C (spontaneous rate, 4.9 +/- 0.3 Hz). A flutter-like pattern of arrhythmia was reproducibly induced by application of stimulus trains (250 pulses, 66.7 Hz), Arrhythmia was characterized by regular and very short cycle length (40-70 ms), each episode lasting from 3 s to >5 min. In control conditions, application of one to five pulse trains was sufficient to induce arrhythmia. However, atropine (but not propranolol) completely blocked arrhythmia induction (10-15 consecutive trains were ineffective). The ability of electrical stimulation to evoke arrhythmia was restored after atropine washout. A milder stimulation protocol(30 pulses, 50 Hz), which was unable to evoke arrhythmia in control conditions, was fully effective in the presence of 1 mu M acetylcholine (ACh). Furthermore, a similar flutter-like pattern could be induced in isolated left atria in the presence of ACh, Our results point out an arrhythmogenic effect of neurally released ACh in the isolated right atrium on atrial electrical stimulation.
dc.description34
dc.description4
dc.description475
dc.description479
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJournal Of Cardiovascular Pharmacology
dc.relationJ. Cardiovasc. Pharmacol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectelectrical stimulation
dc.subjectarrhythmia
dc.subjectacetylcholine
dc.subjectatrial flutter
dc.subjectisolated atria
dc.subjectparasympathetic innervation
dc.subjectIii Antiarrhythmic Drugs
dc.subjectFibrillation Threshold
dc.subjectHeart
dc.subjectMechanisms
dc.subjectCells
dc.subjectAfterdepolarizations
dc.subjectRefractoriness
dc.subjectMyocardium
dc.subjectActivation
dc.subjectStimulus
dc.titleRole of acetylcholine in electrical stimulation-induced arrhythmia in rat isolated atria
dc.typeArtículos de revistas


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