Immunohistochemical Evaluation of Angiogenesis and Tryptase-positive Mast Cell Infiltration in Periapical Lesions

dc.creatorLima, SCA
dc.creatorRizo, VHT
dc.creatorSilva-Sousa, YTC
dc.creatorAlmeida, LY
dc.creatorAlmeida, OP
dc.creatorLeon, JE
dc.date2011
dc.dateDEC
dc.date2014-07-30T18:05:55Z
dc.date2015-11-26T17:48:58Z
dc.date2014-07-30T18:05:55Z
dc.date2015-11-26T17:48:58Z
dc.date.accessioned2018-03-29T00:31:59Z
dc.date.available2018-03-29T00:31:59Z
dc.identifierJournal Of Endodontics. Elsevier Science Inc, v. 37, n. 12, n. 1642, n. 1646, 2011.
dc.identifier0099-2399
dc.identifierWOS:000298126400008
dc.identifier10.1016/j.joen.2011.08.024
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69954
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69954
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289265
dc.descriptionIntroduction: Several studies have linked mast cells (MCs) with angiogenesis. The aim of this study was to correlate angiogenesis with MCs in radicular cyst (RC) and periapical granuloma (PG) cases. Methods: Forty-eight samples of periapical lesions, diagnosed as RC (n = 24) and PG (n = 24), were included. The microvessel density and microvessel area measured through the immunoexpression of CD105 and CD34 and the MC density measured through the immunoexpression of tryptase were performed. Results: MCs were detected in all RCs and PGs (P =.888), mainly in perivascular location and within fibrous stroma. CD34 stained all vessels present in all RC and PG cases. CD105 revealed differential expression, stained preferentially vessels of greater lumen, and showed variable location inside fibrous stroma in both lesions. There was a significant difference of microvessel density determinate by CD34 and CD105 in RCs (r = 0.634, P =.002) and in PGs (r = 0.5709, P =.0036). The difference was also observed when comparing age of the patient in both lesions. Considering the microscopic association between highest concentration of MCs and vascularization, CD105-positive vessels in 50% of RCs and 70.8% of PGs and CD34-positive vessels in 66.7% of RCs and 87.5% of PGs showed areas of close association with MCs. Conclusions: These results suggest differential expression of CD105 within RC and PG. There is no difference in angiogenesis and MC density between RC and PG. Moreover, because of the association between MCs with vessels and fibrous stroma, other possible roles of tryptase, in addition to the angiogenic properties, should also be considered. (J Endod 2011;37:1642-1646)
dc.description37
dc.description12
dc.description1642
dc.description1646
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationJournal Of Endodontics
dc.relationJ. Endod.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAngiogenesis
dc.subjectCD34
dc.subjectCD105 (endoglin)
dc.subjectmast cell
dc.subjectperiapical lesions
dc.subjecttryptase
dc.subjectFibroblast-growth-factor
dc.subjectTumor Angiogenesis
dc.subjectRadicular Cysts
dc.subjectPathogenesis
dc.subjectGranulomas
dc.subjectCarcinoma
dc.subjectAlpha
dc.titleImmunohistochemical Evaluation of Angiogenesis and Tryptase-positive Mast Cell Infiltration in Periapical Lesions
dc.typeArtículos de revistas


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