Impairment of thrombin generation in the early phases of the host response of sepsis

dc.creatorPicoli-Quaino, SK
dc.creatorAlves, BE
dc.creatorFaiotto, VB
dc.creatorMontalvao, SAL
dc.creatorDe Souza, CA
dc.creatorAnnichino-Bizzacchi, JM
dc.creatorDe Paula, EV
dc.date2014
dc.dateFEB
dc.date2014-07-30T18:06:21Z
dc.date2015-11-26T17:48:55Z
dc.date2014-07-30T18:06:21Z
dc.date2015-11-26T17:48:55Z
dc.date.accessioned2018-03-29T00:31:54Z
dc.date.available2018-03-29T00:31:54Z
dc.identifierJournal Of Critical Care. W B Saunders Co-elsevier Inc, v. 29, n. 1, n. 31, n. 36, 2014.
dc.identifier0883-9441
dc.identifier1557-8615
dc.identifierWOS:000328693000006
dc.identifier10.1016/j.jcrc.2013.08.015
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70034
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70034
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289247
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionPurpose: The purpose was to investigate the presence of hypercoagulability in the very early phase of the host response to an infection in the clinical course of sepsis and septic shock. Material and Methods: Twenty-four patients with chemotherapy-associated febrile neutropenia were evaluated at baseline, at the time of fever onset, and 48 hours thereafter using the thrombin generation test, a more physiological and global assay of hemostasis. Results: The rate of thrombin generation was decreased and no signals of systemic hypercoagulability could be observed during the first 48 hours of sepsis. Moreover, patients that evolved to septic shock presented a more significant impairment in thrombin generation than those with noncomplicated sepsis. Conclusions: Patients with sepsis and febrile neutropenia present an impairment in thrombin generation from very early stages of their disease course. These results suggest that the procoagulant in vitro alterations described during sepsis do not necessarily translate into a clinically relevant systemic hypercoagulable state. These findings could help explain why treatment with systemic anticoagulants did not translate to clinical benefits in human sepsis and highlight the need for a better understanding of the hemostatic alterations in sepsis before new treatments targeting coagulation activation are developed. (C) 2014 Elsevier Inc. All rights reserved.
dc.description29
dc.description1
dc.description31
dc.description36
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2011/02829-7]
dc.languageen
dc.publisherW B Saunders Co-elsevier Inc
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJournal Of Critical Care
dc.relationJ. Crit. Care
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectSepsis
dc.subjectThrombin generation
dc.subjectDisseminated intravascular coagulation
dc.subjectDisseminated Intravascular Coagulation
dc.subjectCritically-ill Patients
dc.subjectSeptic Shock
dc.subjectOrgan Dysfunction
dc.subjectNeutropenic Patients
dc.subjectHuman Endotoxemia
dc.subjectCoagulopathy
dc.subjectActivation
dc.subjectManagement
dc.subjectHypercoagulability
dc.titleImpairment of thrombin generation in the early phases of the host response of sepsis
dc.typeArtículos de revistas


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