Immunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss)

dc.creatorArana, S
dc.creatorAlves, VAF
dc.creatorSabino, M
dc.creatorTabata, YA
dc.creatorNonogaki, S
dc.creatorZaidan-Dagli, ML
dc.creatorHernandez-Bazquez, FJ
dc.date2014
dc.dateFEB-APR
dc.date2014-07-30T18:05:55Z
dc.date2015-11-26T17:48:42Z
dc.date2014-07-30T18:05:55Z
dc.date2015-11-26T17:48:42Z
dc.date.accessioned2018-03-29T00:31:38Z
dc.date.available2018-03-29T00:31:38Z
dc.identifierJournal Of Comparative Pathology. Elsevier Sci Ltd, v. 150, n. 41700, n. 258, n. 265, 2014.
dc.identifier0021-9975
dc.identifier1532-3129
dc.identifierWOS:000334141500019
dc.identifier10.1016/j.jcpa.2013.07.003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69955
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69955
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289177
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn mammalian species, profibrogenic cells are activated to become myofibroblasts in response to liver damage. Few studies have examined hepatic myofibroblasts and their role in liver damage in teleosts. The aim of the present study was to investigate the involvement of myofibroblast-like cells in rainbow trout (Oncorhynchus mykiss) with hepatic damage induced by aflatoxin B1 (AFB1). Histopathological and immunohistochemical analyses characterized alterations in the liver stroma during the carcinogenic process. Anti-human a-smooth muscle actin (SMA) and anti-human desmin primary antibodies were used in immunohistochemistry. Only the anti-SMA reagent labelled cells in. trout liver. In the livers of control fish, only smooth muscle in blood vessels and around bile ducts was labelled. In the livers from AFB1-treated fish, SMA-positive cells were present in the stroma surrounding neoplastic lesions and in areas of desmoplastic reaction. These observations indicate that in teleosts, as in mammals, the myofibroblast-like cell is involved in fibrosis associated with liver injury. Chronic liver injury induced in trout by aflatoxin may provide a useful model system for study of the evolution of such mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.
dc.description150
dc.description41700
dc.description258
dc.description265
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundo de Apoio ao Ensino, Pesquisa e Extensao da Universidade Estadual de Campinas (Faepex/Unicamp)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationJournal Of Comparative Pathology
dc.relationJ. Comp. Pathol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectfish
dc.subjecthepatocarcinogenesis
dc.subjectliver fibrosis
dc.subjectmyofibroblast
dc.subjectHepatocellular-carcinoma Cells
dc.subjectMedaka Oryzias-latipes
dc.subjectHepatic Stellate Cells
dc.subjectFat-storing Cells
dc.subjectFish Model
dc.subjectIto-cells
dc.subjectFibrosis
dc.subjectExpression
dc.subjectCirrhosis
dc.subjectLesions
dc.titleImmunohistochemical Evidence for Myofibroblast-like Cells Associated with Liver Injury Induced by Aflatoxin B1 in Rainbow Trout (Oncorhynchus mykiss)
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución