Retinoblastoma Diagnosis: A Proposal Based on the Experience of Centro Infantil Boldrini, Brazil

dc.creatorPalazzi, MA
dc.creatorStephan, C
dc.creatorBrandalise, SR
dc.creatorAguiar, SD
dc.date2013
dc.dateAUG
dc.date2014-07-30T18:27:10Z
dc.date2015-11-26T17:48:35Z
dc.date2014-07-30T18:27:10Z
dc.date2015-11-26T17:48:35Z
dc.date.accessioned2018-03-29T00:31:29Z
dc.date.available2018-03-29T00:31:29Z
dc.identifierPediatric Hematology And Oncology. Informa Healthcare, v. 30, n. 5, n. 379, n. 385, 2013.
dc.identifier0888-0018
dc.identifierWOS:000321772400003
dc.identifier10.3109/08880018.2013.775201
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71090
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71090
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289140
dc.descriptionAdvanced disease is a risk factor for eye loss in patients with retinoblastoma (RB). We still record critical rates of enucleation, especially for unilateral RB due to advanced stages of disease at diagnosis. This retrospective study of 223 RB patient records referred to treatment at Centro Infantil Boldrini, Brazil, between 1978 and 2008, showed that 176 patients (79%) presented intraocular tumors while 47 (21%) already had extraocular involvement. At the time of diagnosis, the age of patients was 26.2 months in the group that had enucleated eyes and 13.7 months in the group that preserved both eyes. Under a multiple logistic regression model, familial history (OR = 0.195; p = .01) and age at diagnosis in months (OR = 1.047; p = .04) were significantly correlated with enucleation. Strategies to early detect RB must be changed in order to offer better chances of ocular preservation with visual function. Authors propose a systematic referral of all children to the ophthalmologist for an indirect ophthalmoscopy once a year in the first two years of life, as a measure to be adopted by all pediatricians in daily routine to early detect the tumor.
dc.description30
dc.description5
dc.description379
dc.description385
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationPediatric Hematology And Oncology
dc.relationPediatr. Hematol. Oncol.
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectearly diagnosis
dc.subjectophthalmic pathology
dc.subjectpediatric oncology
dc.subjectretinoblastoma
dc.subjectIntraocular Retinoblastoma
dc.subjectIntraarterial Chemotherapy
dc.subjectUnilateral Retinoblastoma
dc.subjectCurrent Management
dc.subjectSurvival
dc.subjectSchool
dc.subjectStage
dc.titleRetinoblastoma Diagnosis: A Proposal Based on the Experience of Centro Infantil Boldrini, Brazil
dc.typeArtículos de revistas


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