Orchidopexy restores morphometric-stereologic changes in the caput epididymis and daily sperm production in cryptorchidic mice, although sperm transit time and fertility parameters remain impaired

dc.creatorGarcia, PV
dc.creatorArroteia, KF
dc.creatorJoazeiro, PP
dc.creatorMesquita, SDP
dc.creatorKempinas, WD
dc.creatorPereira, LAV
dc.date2011
dc.dateSEP
dc.date2014-07-30T18:03:39Z
dc.date2015-11-26T17:48:33Z
dc.date2014-07-30T18:03:39Z
dc.date2015-11-26T17:48:33Z
dc.date.accessioned2018-03-29T00:31:26Z
dc.date.available2018-03-29T00:31:26Z
dc.identifierFertility And Sterility. Elsevier Science Inc, v. 96, n. 3, n. 739, n. 744, 2011.
dc.identifier0015-0282
dc.identifierWOS:000294417000055
dc.identifier10.1016/j.fertnstert.2011.06.036
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69720
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69720
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289127
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionObjective: To evaluate the changes in the caput epididymis following cryptorchidism and orchidopexy. Design: Experimental study in a research laboratory. Setting: Reproductive biology research laboratory. Animal(s): Immature male and mature female mice (C57BL/6). Intervention(s): Experimental cryptorchidism and orchidopexy. Main Outcome Measure(s): Morphometric-stereologic analyses, serum testosterone dosage, immunohistochemical staining of the antigen TRA54 (testicular germ cells immunized to a rat monoclonal antibody), smooth muscle alpha-actin (SM alpha-actin) and SM myosin heavy chain, sperm transit time, and fertility parameters. Result(s): There was a significant reduction in the morphometric-stereologic parameters in the cryptorchidic mice. These parameters demonstrated significant recovery following orchidopexy. Staining for an androgen-dependent antigen, TRA54, was observed in all groups. SM alpha-actin and SM myosin heavy chain staining was significantly increased in the cryptorchidism group but stable in the orchidopexy group. Despite the recovery of daily sperm production in the testes, the sperm transit time in the epididymis and fertility parameters remained significantly reduced in the orchidopexy group. Conclusion(s): In cryptorchidic animals, there was an acceleration of sperm passage through the epididymal duct. Orchidopexy did not restore the normal passage time. Accordingly, there was a significant reduction in the fertility parameters in the cryptorchidic group that were not fully recovered following orchidopexy. (Fertil Steril (R) 2011;96:739-44. (C)2011 by American Society for Reproductive Medicine.)
dc.description96
dc.description3
dc.description739
dc.description744
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [06/00096-4]
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationFertility And Sterility
dc.relationFertil. Steril.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCryptorchidism
dc.subjectorchidopexy
dc.subjectepididymis
dc.subjectsperm
dc.subjectfertility
dc.subjectLong-term Consequences
dc.subjectVas-deferens
dc.subjectSubsequent Orchidopexy
dc.subjectProcessus-vaginalis
dc.subjectTesticular Function
dc.subjectMouse Testis
dc.subjectAdult-mouse
dc.subjectT-antigen
dc.subjectSpermatogenesis
dc.subjectTemperature
dc.titleOrchidopexy restores morphometric-stereologic changes in the caput epididymis and daily sperm production in cryptorchidic mice, although sperm transit time and fertility parameters remain impaired
dc.typeArtículos de revistas


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