Response to Cold Pressor Test Predicts Long-Term Changes in Pulse Wave Velocity in Men

dc.creatorBellinazzi, VR
dc.creatorSposito, AC
dc.creatorSchreiber, R
dc.creatorMill, JG
dc.creatorKrieger, JE
dc.creatorPereira, AC
dc.creatorNadruz, W
dc.date2014
dc.dateFEB
dc.date2014-07-30T18:23:26Z
dc.date2015-11-26T17:48:19Z
dc.date2014-07-30T18:23:26Z
dc.date2015-11-26T17:48:19Z
dc.date.accessioned2018-03-29T00:31:08Z
dc.date.available2018-03-29T00:31:08Z
dc.identifierAmerican Journal Of Hypertension. Oxford Univ Press, v. 27, n. 2, n. 157, n. 161, 2014.
dc.identifier0895-7061
dc.identifier1941-7225
dc.identifierWOS:000329128100003
dc.identifier10.1093/ajh/hpt213
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71050
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71050
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289054
dc.descriptionAortic stiffness is associated with increased cardiovascular mortality. However, the determinants of aortic stiffness progression are not fully established. This study evaluated the predictive value of blood pressure (BP) response to cold pressor test (CPT) in the progression of carotidfemoral pulse wave velocity (PWV) in men and women. A total of 408 individuals (165 men, 243 women) from Vitoria, Brazil, underwent BP evaluation, clinical and laboratorial investigations, and CPT and PWV assessment. Five years later, the studied individuals were re-evaluated, except for the CPT. In men, 5-year PWV change correlated inversely with baseline PWV (P < 0.001) and directly with BP response to CPT (P < 0.05) and 5-year BP change (P < 0.05). In women, 5-year PWV change correlated inversely with baseline PWV (P < 0.001) and directly with age (P < 0.01), glycemia (P < 0.05) and 5-year BP change (P < 0.05) but not with BP response to CPT. Further linear regression analysis showed that 5-year PWV change was associated with baseline PWV, systolic BP response to CPT, and 5-year systolic BP change in men and with baseline PWV, age, glycemia, and 5-year systolic BP change in women. BP response to CPT was a predictor of PWV progression in men after 5 years of follow-up. These findings provide further insights into the pathophysiologic mechanisms of arterial stiffness, suggesting that elevated sympathetic reactivity may be a predisposing factor for future increases in aortic stiffness, at least in men.
dc.description27
dc.description2
dc.description157
dc.description161
dc.languageen
dc.publisherOxford Univ Press
dc.publisherOxford
dc.publisherInglaterra
dc.relationAmerican Journal Of Hypertension
dc.relationAm. J. Hypertens.
dc.rightsfechado
dc.rightshttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.sourceWeb of Science
dc.subjectarterial stiffness
dc.subjectblood pressure
dc.subjecthypertension
dc.subjectsex differences
dc.subjectsympathetic reactivity
dc.subjectArterial Stiffness
dc.subjectResistant Hypertension
dc.subjectAortic Stiffness
dc.subjectFollow-up
dc.subjectDeterminants
dc.subjectSensitivity
dc.titleResponse to Cold Pressor Test Predicts Long-Term Changes in Pulse Wave Velocity in Men
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución