HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome - Brazilian Metabolic Syndrome Study (BRAMS)

dc.creatorGeloneze, B
dc.creatorVasques, ACJ
dc.creatorStabe, CFC
dc.creatorPareja, JC
dc.creatorRosado, LEFPD
dc.creatorde Queiroz, EC
dc.creatorTambascia, MA
dc.date2009
dc.dateMAR
dc.date2014-07-30T18:03:27Z
dc.date2015-11-26T17:48:12Z
dc.date2014-07-30T18:03:27Z
dc.date2015-11-26T17:48:12Z
dc.date.accessioned2018-03-29T00:31:01Z
dc.date.available2018-03-29T00:31:01Z
dc.identifierArquivos Brasileiros De Endocrinologia E Metabologia. Sbem-soc Brasil Endocrinologia & Metabologia, v. 53, n. 2, n. 281, n. 287, 2009.
dc.identifier0004-2730
dc.identifierWOS:000265288400020
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69604
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69604
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289022
dc.descriptionObjective: To investigate cut-off values for HOMA1-IR and HOMA2-IR to identify insulin resistance (IR) and metabolic syndrome (MS), and to assess the association of the indexes with components of the MS. Methods: Nondiabetic subjects from the Brazilian Metabolic Syndrome Study were studied (n = 1,203, 18 to 78 years). The cut-off values for IR were determined from the 9011 percentile in the healthy group (n = 297) and, for MS, a ROC curve was generated for the total sample. Results: In the healthy group, HOMA-IR indexes were associated with central obesity, triglycerides and total cholesterol (p < 0.001). The cut-off values for IR were: HOMA1-IR > 2.7 and HOMA2-IR > 1.8; and, for MS were: HOMA1-IR > 2.3 (sensitivity: 76.8%; specificity: 66.7%) and HOMA2-IR > 1.4 (sensitivity: 79.2%; specificity: 61.2%). Conclusions: The cut-off values identified for HOMA1-IR and HOMA2-IR indexes have a clinical and epidemiological application for identifying IR and MS in Westernized admixtured multi-ethnic populations. Arq Bras Endocrinol Metab. 2009;53(2):281-287.
dc.description53
dc.description2
dc.description281
dc.description287
dc.languageen
dc.publisherSbem-soc Brasil Endocrinologia & Metabologia
dc.publisherRio De Janeiro, Rj
dc.publisherBrasil
dc.relationArquivos Brasileiros De Endocrinologia E Metabologia
dc.relationArq. Bras. Endocrinol. Metabol.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectHomeostasis model assessment
dc.subjectmetabolic syndrome
dc.subjectinsulin resistance
dc.subjectabdominal obesity
dc.subjectHomeostasis Model Assessment
dc.subjectCardiovascular-disease
dc.subjectNormal-weight
dc.subjectPrevalence
dc.subjectPlasma
dc.subjectQuantification
dc.subjectPopulation
dc.subjectOverweight
dc.subjectGlucose
dc.subjectObesity
dc.titleHOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome - Brazilian Metabolic Syndrome Study (BRAMS)
dc.typeArtículos de revistas


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