Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes

dc.creatorMawardi, H
dc.creatorElad, S
dc.creatorCorrea, ME
dc.creatorStevenson, K
dc.creatorWoo, SB
dc.creatorAlmazrooa, S
dc.creatorHaddad, R
dc.creatorAntin, JH
dc.creatorSoiffer, R
dc.creatorTreister, N
dc.date2011
dc.dateJUN
dc.date2014-07-30T18:03:33Z
dc.date2015-11-26T17:48:08Z
dc.date2014-07-30T18:03:33Z
dc.date2015-11-26T17:48:08Z
dc.date.accessioned2018-03-29T00:30:55Z
dc.date.available2018-03-29T00:30:55Z
dc.identifierBone Marrow Transplantation. Nature Publishing Group, v. 46, n. 6, n. 884, n. 891, 2011.
dc.identifier0268-3369
dc.identifierWOS:000291383100018
dc.identifier10.1038/bmt.2011.77
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69655
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69655
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1288993
dc.descriptionLate complications of allogeneic hematopoietic stem cell transplantation (HSCT) include a risk of secondary malignancies. Optimization for early diagnosis and treatment of oral premalignant or malignant lesions requires an assessment of potential predisposing risk factors. The medical records of patients who developed oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) following allogeneic-HSCT were reviewed. Data on HSCT course, chronic graft-versus-host disease (cGVHD), and clinical outcome were recorded; landmark survival was calculated. Twenty-six patients with OED (n = 8) and OSCC (n = 18) were identified with a median follow-up of 26.5 and 21.5 months, respectively. Premalignant and malignant oral lesions were diagnosed at a median time of 2.5 and 8 years after HSCT, respectively. Chronic GVHD was present in 96% of patients and of these, 96% had oral involvement. Multifocal oral cancer was found in 28% of cases, and localized recurrence was observed in 44% of cases. These results suggest that oral cGVHD may be considered a potential risk factor for the development of OSCC following allogeneic-HSCT. The observation that oral cancers were frequently multifocal and recurred locally suggests that these cancers may be more aggressive. Vigilant follow-up and coordination of care are critical. Bone Marrow Transplantation (2011) 46, 884-891; doi: 10.1038/bmt.2011.77; published online 4 April 2011
dc.description46
dc.description6
dc.description884
dc.description891
dc.descriptionNIH [CA142106]
dc.descriptionNIH [CA142106]
dc.languageen
dc.publisherNature Publishing Group
dc.publisherLondon
dc.publisherInglaterra
dc.relationBone Marrow Transplantation
dc.relationBone Marrow Transplant.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjecthematopoietic
dc.subjectoral epithelial dysplasia
dc.subjectsquamous cell carcinoma
dc.subjectallogeneic
dc.subjecttransplantation
dc.subjectBone-marrow-transplantation
dc.subjectVersus-host-disease
dc.subjectChildhood Acute-leukemia
dc.subjectSevere Aplastic-anemia
dc.subjectSecondary Malignancies
dc.subjectRisk-factors
dc.subjectFanconi-anemia
dc.subjectSolid Cancers
dc.subjectTopical Application
dc.subjectGenomic Alterations
dc.titleOral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución