Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippocampal neurons but does not alter learning and memory performance in adult offspring

dc.creatorLopes, A
dc.creatorTorres, DB
dc.creatorRodrigues, AJ
dc.creatorCerqueira, JJ
dc.creatorPego, JM
dc.creatorSousa, N
dc.creatorGontijo, JAR
dc.creatorBoer, PA
dc.date2013
dc.dateMAY
dc.date2014-07-30T17:47:56Z
dc.date2015-11-26T17:48:07Z
dc.date2014-07-30T17:47:56Z
dc.date2015-11-26T17:48:07Z
dc.date.accessioned2018-03-29T00:30:54Z
dc.date.available2018-03-29T00:30:54Z
dc.identifierInternational Journal Of Developmental Neuroscience. Pergamon-elsevier Science Ltd, v. 31, n. 3, n. 151, n. 156, 2013.
dc.identifier0736-5748
dc.identifierWOS:000316975400001
dc.identifier10.1016/j.ijdevneu.2012.12.003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68035
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68035
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1288990
dc.descriptionStudies have demonstrated that nutrient deficiency during pregnancy or in early postnatal life results in structural abnormalities in the offspring hippocampus and in cognitive impairment. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairments associated with structural changes in the hippocampus, we carried out a detailed morphometric analysis of the hippocampus of male adult rats together with the behavioral characterization of these animals in the Morris water maze (MWM). Our results demonstrate that gestational protein restriction leads to a decrease in total basal dendritic length and in the number of intersections of CA3 pyramidal neurons whereas the cytoarchitecture of CA1 and dentate gyrus remained unchanged. Despite presenting significant structural rearrangements, we did not observe impairments in the MWM test. Considering the clear dissociation between the behavioral profile and the hippocampus neuronal changes, the functional significance of dendritic remodeling in fetal processing remains undisclosed. (c) 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
dc.description31
dc.description3
dc.description151
dc.description156
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationInternational Journal Of Developmental Neuroscience
dc.relationInt. J. Dev. Neurosci.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectFetal programming
dc.subjectHippocampus
dc.subjectDendritic remodeling
dc.subjectBehavior
dc.subjectProtein restriction
dc.subjectChronic Psychosocial Stress
dc.subjectPyramidal Neurons
dc.subjectBlood-pressure
dc.subjectMaternal Undernutrition
dc.subjectSpatial Navigation
dc.subjectApical Dendrites
dc.subjectPrenatal Stress
dc.subjectRat-brain
dc.subjectGlucocorticoid Exposure
dc.subjectPresynaptic Terminals
dc.titleGestational protein restriction induces CA3 dendritic atrophy in dorsal hippocampal neurons but does not alter learning and memory performance in adult offspring
dc.typeArtículos de revistas


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