Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

dc.creatorCaricilli, AM
dc.creatorNascimento, PH
dc.creatorPauli, JR
dc.creatorTsukumo, DML
dc.creatorVelloso, LA
dc.creatorCarvalheira, JB
dc.creatorSaad, MJA
dc.date2008
dc.dateDEC
dc.date2014-11-18T07:32:47Z
dc.date2015-11-26T17:47:50Z
dc.date2014-11-18T07:32:47Z
dc.date2015-11-26T17:47:50Z
dc.date.accessioned2018-03-29T00:30:34Z
dc.date.available2018-03-29T00:30:34Z
dc.identifierJournal Of Endocrinology. Bioscientifica Ltd, v. 199, n. 3, n. 399, n. 406, 2008.
dc.identifier0022-0795
dc.identifierWOS:000261503100006
dc.identifier10.1677/JOE-08-0354
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80650
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80650
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80650
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1288901
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe aims of the present study were to investigate the expression of toll-like receptor-2 (TLR2) in muscle and white adipose tissue (WAT) of diet-induced obesity (DIO) mice, and also the effects of its inhibition, with the use of TLR2 antisense oligonucleotide (ASON), on insulin sensitivity and signaling, The expression of TLR2 was increased in muscle and WAT of DIO mice, compared with those that received standard chow. Inhibition of TLR2 in DIO mice, by TLR2 ASON, improved insulin and signaling in muscle and WAT In addition, data show that the inhibition of TLR2 expression prevents the activation of IKBKB, MAPK8, and serine phosphorylation of IRS1 in DIO mice, suggesting that TLR2 is a key modulator of the crosstalk between inflammatory and metabolic pathways. We, therefore, suggest chat a selective interference with TLR2 presents an attractive opportunity for the treatment of insulin resistance in obesity and type 2 diabetes.
dc.description199
dc.description3
dc.description399
dc.description406
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherBioscientifica Ltd
dc.publisherBristol
dc.publisherInglaterra
dc.relationJournal Of Endocrinology
dc.relationJ. Endocrinol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectSerine Phosphorylation
dc.subjectTargeted Disruption
dc.subjectInduced Obesity
dc.subjectResistance
dc.subjectToll-like-receptor-4
dc.subjectSubstrate-1
dc.subjectJnk
dc.subjectActivation
dc.subjectMechanism
dc.subjectPathways
dc.titleInhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución