Effects of experimental inoculation of bovine respiratory syncytial virus in different inbred mice lineages: Establishment of a murine model for BRSV infection

dc.creatorSpilki, FR
dc.creatorAlmeida, RS
dc.creatorFerreira, HL
dc.creatorGameiro, J
dc.creatorVerinaud, L
dc.creatorArns, CW
dc.date2006
dc.dateDEC 20
dc.date2014-11-18T07:01:30Z
dc.date2015-11-26T17:47:38Z
dc.date2014-11-18T07:01:30Z
dc.date2015-11-26T17:47:38Z
dc.date.accessioned2018-03-29T00:30:18Z
dc.date.available2018-03-29T00:30:18Z
dc.identifierVeterinary Microbiology. Elsevier Science Bv, v. 118, n. 41732, n. 161, n. 168, 2006.
dc.identifier0378-1135
dc.identifierWOS:000242792700001
dc.identifier10.1016/j.vetmic.2006.07.011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64167
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/64167
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64167
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1288839
dc.descriptionBovine respiratory syncytial virus (BRSV), a member of the subfamily Pneumovirinae, family Paramyxoviridae, is a major cause of respiratory disorders in young cattle. A number of studies were conducted to validate a reliable animal model for the infection, since BRSV inoculation on the natural host is costly and often unsuccessful. Unfortunately, after inoculation of BRSV in Balb/C mice, viral replication may be detected; however, evident pathological alterations are absent on the experimentally infected animals. In order to establish a mice model that could be used further for preliminary studies of pathological and immunological aspects of BRSV infection, three mice inbred lineages (Balb/C, A/J and C57BL6), possessing different genetic backgrounds, were tested about its susceptibility to the inoculation with BRSV. Animals were inoculated through the nasal and ocular routes and were observed after inoculation. At 7 days post-inoculation (dpi) animals were necropsied and virological (virus isolation and viral nucleic acid amplification) as well as histopathological examinations were performed. A/J and C57BL6 showed interstitial pneumonia, when compared to the Balb/C group. These findings shows that mice may constitute a suitable model for the study of BRSV infections, depending on the mice strain used for experimental inoculations. (c) 2006 Elsevier B.V. All rights reserved.
dc.description118
dc.description41732
dc.description161
dc.description168
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationVeterinary Microbiology
dc.relationVet. Microbiol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectbovine respiratory syncytial virus
dc.subjectBRSV
dc.subjectinbred mice
dc.subjectmurine model
dc.subjectexperimental infection
dc.subjectRT-Nested-PCR
dc.subjectTract Infection
dc.subjectVaccine
dc.subjectRsv
dc.subjectSusceptibility
dc.subjectCalves
dc.subjectGlycoprotein
dc.subjectPathogenesis
dc.subjectResponses
dc.subjectExposure
dc.subjectAntibody
dc.titleEffects of experimental inoculation of bovine respiratory syncytial virus in different inbred mice lineages: Establishment of a murine model for BRSV infection
dc.typeArtículos de revistas


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