Gastroprotective Effect of the Ethanolic Extract and Fractions obtained from Syngonanthus bisulcatus Rul.

dc.creatorBatista, LM
dc.creatorde Almeida, ABA
dc.creatorLima, GRD
dc.creatorFalcao, HD
dc.creatorFerreira, AL
dc.creatorMagri, LD
dc.creatorCoelho, RG
dc.creatorCalvo, TR
dc.creatorVilegas, W
dc.creatorBrito, ARMS
dc.date2013
dc.date2014-07-30T17:47:30Z
dc.date2015-11-26T17:47:10Z
dc.date2014-07-30T17:47:30Z
dc.date2015-11-26T17:47:10Z
dc.date.accessioned2018-03-29T00:29:47Z
dc.date.available2018-03-29T00:29:47Z
dc.identifierRecords Of Natural Products. Acg Publications, v. 7, n. 1, n. 35, n. 44, 2013.
dc.identifier1307-6167
dc.identifierWOS:000319555200005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67816
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67816
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1288704
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionSyngonanthus bisulcatus Rul., popularly known in Brazil as "sempre-vivas chapadeira", is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E-2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. The observed gastroprotective effects of S. bisulcatus probably involve the participation of both mucus and prostaglandins, integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.
dc.description7
dc.description1
dc.description35
dc.description44
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherAcg Publications
dc.publisherGebze-kocaeli
dc.publisherTurquia
dc.relationRecords Of Natural Products
dc.relationRec. Nat. Prod.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectMedicinal plants
dc.subjecteriocaulaceae
dc.subjectsyngonanthus bisulcatus
dc.subjectgastric ulcer
dc.subjectgastroprotective activity
dc.subjectNonsteroidal Antiinflammatory Drugs
dc.subjectAnti-ulcerogenic Activity
dc.subjectGastric-mucosal Lesions
dc.subjectAntiulcerogenic Activity
dc.subjectLeaf Extract
dc.subjectRats
dc.subjectStress
dc.subjectUlcer
dc.subjectIndomethacin
dc.subjectProstaglandin
dc.titleGastroprotective Effect of the Ethanolic Extract and Fractions obtained from Syngonanthus bisulcatus Rul.
dc.typeArtículos de revistas


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