Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy

dc.creatorOliveira-Paula, GH
dc.creatorLacchini, R
dc.creatorCoeli-Lacchini, FB
dc.creatorMoreno, H
dc.creatorTanus-Santos, JE
dc.date2013
dc.dateFEB 25
dc.date2014-07-30T14:33:20Z
dc.date2015-11-26T17:45:22Z
dc.date2014-07-30T14:33:20Z
dc.date2015-11-26T17:45:22Z
dc.date.accessioned2018-03-29T00:27:43Z
dc.date.available2018-03-29T00:27:43Z
dc.identifierGene. Elsevier Science Bv, v. 515, n. 2, n. 391, n. 395, 2013.
dc.identifier0378-1119
dc.identifierWOS:000315307100022
dc.identifier10.1016/j.gene.2012.12.059
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60094
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60094
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1288164
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionHypertension is a multifactorial disorder associated with increased inducible nitric oxide synthase (iNOS) expression and activity. While genetic polymorphisms affect iNOS expression, it is not known whether iNOS gene polymorphisms affect the susceptibility to hypertension and the responses to antihypertensive therapy. This study aimed at assessing whether iNOS polymorphisms ((CCTTT)(n), g.-1026C>A, and g.2087G>A) and haplotypes are associated with hypertension and with responsiveness to drug therapy. We studied 115 well controlled hypertensive patients (HTN), 82 hypertensive patients resistant to optimized antihypertensive therapy (RHTN), and 113 normotensive healthy subjects (NT). Genotypings were carried out using real-time polymerase chain reaction (PCR) and PCR amplification followed by capillary electrophoresis. The software PHASE 2.1 was used to estimate the haplotype frequencies in each group. Variant genotypes (GA + AA) for the g.2087G>A polymorphism were more commonly found in hypertensive patients (HTN + RHTN) than in normotensives (P=0.016; OR=2.05). We found no associations between genotypes and responsiveness to therapy (P>0.05). The S-C-A haplotype was more commonly found in hypertensive patients (HTN + RHTN) than in normotensives (P=0.014; OR=6.07). Interestingly, this haplotype was more commonly found in the HTN group than in the RHTN group (P=0.012; OR=0.14). Our findings indicate that the g.2087G>A polymorphism in the iNOS gene affects the susceptibility to hypertension. Moreover, while the S-C-A haplotype is associated with hypertension, it is also associated with responsiveness to antihypertensive therapy. (C) 2012 Elsevier B.V. All rights reserved.
dc.description515
dc.description2
dc.description391
dc.description395
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationGene
dc.relationGene
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectHaplotype
dc.subjectHypertension
dc.subjectInducible nitric oxide synthase
dc.subjectPolymorphisms
dc.subjectResistant hypertension
dc.subjectHigh-blood-pressure
dc.subjectResistant Hypertension
dc.subjectOxidative Stress
dc.subjectRenovascular Hypertension
dc.subjectRefractory Hypertension
dc.subjectEndothelial Dysfunction
dc.subjectEnos Haplotypes
dc.subjectMessenger-rna
dc.subjectRats
dc.subjectExpression
dc.titleInducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy
dc.typeArtículos de revistas


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