Evolution and involution of atherosclerosis and its relationship with vascular reactivity in hypercholesterolemic rabbits

dc.creatorOzaki, MR
dc.creatorde Almeida, EA
dc.date2013
dc.dateMAR
dc.date2014-07-30T17:30:00Z
dc.date2015-11-26T17:44:34Z
dc.date2014-07-30T17:30:00Z
dc.date2015-11-26T17:44:34Z
dc.date.accessioned2018-03-29T00:26:44Z
dc.date.available2018-03-29T00:26:44Z
dc.identifierExperimental And Toxicologic Pathology. Elsevier Gmbh, Urban & Fischer Verlag, v. 65, n. 3, n. 297, n. 304, 2013.
dc.identifier0940-2993
dc.identifierWOS:000315076900009
dc.identifier10.1016/j.etp.2011.09.006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66142
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66142
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287907
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground and objectives: The aim of this study is to verify the evolution and involution of experimental atherosclerosis in rabbits through the study of endothelial function, lipids and tissue lipid peroxidation, macro and microscopic quantification of aortic atherosclerosis. Methods: Thirty male New Zealand white rabbits were divided into six groups (n = 5): G1 normal diet; G2: hypercholesterolemic receiving 0.5% of cholesterol diet for 4 months; G3: hypercholesterolemic diet for 4 months after normal diet for more 4 months; G4: hypercholesterolemic diet for 4 months plus normal diet and rosuvastatin for 1 month, G5: hypercholesterolemic diet for 4 months plus normal diet and rosuvastatin for 2 months, G6: hypercholesterolemic diet for 4 months plus normal diet and rosuvastatin for 4 months. Rosuvastatin was administered at a dosage of 5 mg dissolved in 150 ml of water daily. At the end of the experiment were measured: total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), tissue cholesterol (CAO), lipid peroxidation tissue (MDA). Endothelial function (RMAX) was studied in a segment of thoracic aorta, through curve-effect of acetylcholine and sodium nitroprusside. The amount of atherosclerosis was determined by measurement of the arterial lesion, through software, after staining with Sudan IV and histological staining. Results: In relation the water the rabbits drank 60-70 ml all day. It was seen significantly increase in all parameters at G2 both biochemical and tissue. In the group G3 it was seen significantly decrease in plasma lipids levels and tissue cholesterol. Treated groups G4, G5 and G6 all showed a decreased plasma lipid levels, only at G6 group it was noted a tissue cholesterol, tissue peroxidation and quantification of atherosclerosis, which showed a significant decrease. In relation the endothelial function only G6 improve significantly. Interpretation and conclusions: Our findings indicated that the treatment with rosuvastatin for 4 months is more efficient because improve the endothelial function significantly. (C) 2011 Elsevier GmbH. All rights reserved.
dc.description65
dc.description3
dc.description297
dc.description304
dc.descriptionFAEPEX (UNICAMP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.publisherJena
dc.publisherAlemanha
dc.relationExperimental And Toxicologic Pathology
dc.relationExp. Toxicol. Pathol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAtherosclerosis
dc.subjectRabbits
dc.subjectEndothelial dysfunction
dc.subjectRosuvastatin
dc.subjectLipid peroxidation
dc.subjectArterial Smooth-muscle
dc.subjectCoronary-heart-disease
dc.subjectCholesterol Levels
dc.subjectRegression
dc.subjectTrial
dc.subjectSimvastatin
dc.subjectPravastatin
dc.subjectPrevention
dc.subjectRelaxation
dc.subjectTransport
dc.titleEvolution and involution of atherosclerosis and its relationship with vascular reactivity in hypercholesterolemic rabbits
dc.typeArtículos de revistas


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