Effect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice

dc.creatorDe Souza, PAT
dc.creatorMarques, MJ
dc.creatorLima, CAH
dc.creatorMatheus, SMM
dc.date2011
dc.date2014-07-30T17:05:27Z
dc.date2015-11-26T17:44:04Z
dc.date2014-07-30T17:05:27Z
dc.date2015-11-26T17:44:04Z
dc.date.accessioned2018-03-29T00:26:13Z
dc.date.available2018-03-29T00:26:13Z
dc.identifierInternational Journal Of Morphology. Soc Chilena Anatomia, v. 29, n. 4, n. 1357, n. 1363, 2011.
dc.identifier0717-9502
dc.identifierWOS:000302190500048
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63814
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63814
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287773
dc.descriptionDuchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies.
dc.description29
dc.description4
dc.description1357
dc.description1363
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionFundunesp [01268/11-DFP]
dc.languageen
dc.publisherSoc Chilena Anatomia
dc.publisherTemuco
dc.publisherChile
dc.relationInternational Journal Of Morphology
dc.relationInt. J. Morphol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectMuscle fiber
dc.subjectDuchenne muscular dystrophy
dc.subjectCitrus aurantium L.
dc.subjectmdx mouse
dc.subjectMuscle regeneration
dc.subjectCentral nuclei
dc.subjectCreatine kinase
dc.subjectDuchenne Muscular-dystrophy
dc.subjectMouse
dc.subjectGlycoprotein
dc.subjectOrganization
dc.subjectFlavonoids
dc.subjectMechanisms
dc.subjectExpression
dc.subjectInjuries
dc.subjectEvents
dc.subjectRepair
dc.titleEffect of Citrus aurantium L. Essential Oil on Muscle Regeneration in Mdx Mice
dc.typeArtículos de revistas


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