Effect of Brazilian Propolis on Exacerbation of Respiratory Syncytial Virus Infection in Mice Exposed to Tetrabromobisphenol A, a Brominated Flame Retardant

dc.creatorTakeshita, T
dc.creatorWatanabe, W
dc.creatorToyama, S
dc.creatorHayashi, Y
dc.creatorHonda, S
dc.creatorSakamoto, S
dc.creatorMatsuoka, S
dc.creatorYoshida, H
dc.creatorTakeda, S
dc.creatorHidaka, M
dc.creatorTsutsumi, S
dc.creatorYasukawa, K
dc.creatorPark, YK
dc.creatorKurokawa, M
dc.date2013
dc.date2014-07-30T17:05:23Z
dc.date2015-11-26T17:43:49Z
dc.date2014-07-30T17:05:23Z
dc.date2015-11-26T17:43:49Z
dc.date.accessioned2018-03-29T00:25:55Z
dc.date.available2018-03-29T00:25:55Z
dc.identifierEvidence-based Complementary And Alternative Medicine. Hindawi Publishing Corporation, 2013.
dc.identifier1741-427X
dc.identifier1741-4288
dc.identifierWOS:000326563600001
dc.identifier10.1155/2013/698206
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63774
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63774
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287699
dc.descriptionTetrabromobisphenol A (TBBPA), a brominated flame retardant, has been found to exacerbate pneumonia in respiratory syncytial virus- (RSV-) infected mice. We examined the effect of Brazilian propolis (AF-08) on the exacerbation of RSV infection by TBBPA exposure in mice. Mice were fed a powdered diet mixed with 1% TBBPA alone, 0.02% AF-08 alone, or 1% TBBPA and 0.02% AF-08 for four weeks and then intranasally infected with RSV. TBBPA exposure increased the pulmonary virus titer and level of IFN-gamma, a representative marker of pneumonia due to RSV infection, in the lungs of infected mice without toxicity. AF-08 was significantly effective in reducing the virus titers and IFN-gamma level increased by TBBPA exposure. Also, AF-08 significantly reduced proinflammatory cytokine (TNF-alpha and IL-6) levels in the lungs of RSV-infected mice with TBBPA exposure, but Th2 cytokine (IL-4 and IL-10) levels were not evidently increased. Neither TBBPA exposure nor AF-08 treatment affected the anti-RSV antibody production in RSV-infected mice. In flow cytometry analysis, AF-08 seemed to be effective in reducing the ratio of pulmonary CD8a(+) cells in RSV-infected mice with TBBPA exposure. TBBPA and AF-08 did not exhibit anti-RSV activity in vitro. Thus, AF-08 probably ameliorated pneumonia exacerbated by TBBPA exposure in RSV-infected mice by limiting excess cellular immune responses.
dc.descriptionJapan Society for the Promotion of Science and Health and Labour Sciences [23590161, 24790182]
dc.descriptionMinistry of Health, Labour and Welfare of Japan
dc.descriptionJapan Society for the Promotion of Science and Health and Labour Sciences [23590161, 24790182]
dc.languageen
dc.publisherHindawi Publishing Corporation
dc.publisherNew York
dc.publisherEUA
dc.relationEvidence-based Complementary And Alternative Medicine
dc.relationEvid.-based Complement Altern. Med.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectDecabrominated Diphenyl Ether
dc.subjectDelayed-type Hypersensitivity
dc.subjectIn-vitro
dc.subjectOffspring Mice
dc.subjectDevelopmental Immunotoxicity
dc.subjectInfluenza Infection
dc.subjectMeasles-virus
dc.subjectAssay System
dc.subjectKakkon-to
dc.subjectPoliovirus
dc.titleEffect of Brazilian Propolis on Exacerbation of Respiratory Syncytial Virus Infection in Mice Exposed to Tetrabromobisphenol A, a Brominated Flame Retardant
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución