Comparison of Diagnostic Tests in Distinct Well-Defined Conditions Related to Dry Eye Disease

dc.creatorAlves, M
dc.creatorReinach, PS
dc.creatorPaula, JS
dc.creatorCruz, AAVE
dc.creatorBachette, L
dc.creatorFaustino, J
dc.creatorAranha, FP
dc.creatorVigorito, A
dc.creatorde Souza, CA
dc.creatorRocha, EM
dc.date2014
dc.dateMAY 21
dc.date2014-07-30T14:00:09Z
dc.date2015-11-26T17:43:33Z
dc.date2014-07-30T14:00:09Z
dc.date2015-11-26T17:43:33Z
dc.date.accessioned2018-03-29T00:25:37Z
dc.date.available2018-03-29T00:25:37Z
dc.identifierPlos One. Public Library Science, v. 9, n. 5, 2014.
dc.identifier1932-6203
dc.identifierWOS:000336730600069
dc.identifier10.1371/journal.pone.0097921
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56232
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56232
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1287620
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPurpose: This study compares signs, symptoms and predictive tools used to diagnose dry eye disease (DED) and ocular surface disorders in six systemic well-defined and non-overlapping diseases. It is well known that these tests are problematic because of a lack of agreement between them in identifying these conditions. Accordingly, we provide here a comparative clinical profile analysis of these different diseases. Methods: A spontaneous and continuous sample of patients with Sjogren's syndrome (SS) (n = 27), graft-versus-host-disease (GVHD) (n = 28), Graves orbitopathy (n = 28), facial palsy (n = 8), diabetes mellitus without proliferative retinopathy (n = 14) and glaucoma who chronically received topical drugs preserved with benzalkonium chloride (n = 20) were enrolled. Evaluation consisted of a comprehensive protocol encompassing: (1) structured questionnaire - Ocular Surface Disease Index (OSDI); (2) tear osmolarity (TearLab Osmolarity System - Ocusense); (3) tear film break-up time (TBUT); (4) fluorescein and lissamine green staining; (5) Schirmer test and (6) severity grading. Results: One hundred and twenty five patients (aged 48.8 years-old +/- 14.1, male:female ratio = 0.4) were enrolled in the study, along with 24 age and gender matched controls. Higher scores on DED tests were obtained in Sjogren Syndrome (P<0.05), except for tear film osmolarity that was higher in diabetics (P<0.001) and fluorescein staining, that was higher in facial palsy (P<0.001). TFBUT and OSDI correlated better with other tests. The best combination of diagnostic tests for DED was OSDI, TBUT and Schirmer test (sensitivity 100%, specificity 95% and accuracy 99.3%). Conclusions: DED diagnostic test results present a broad range of variability among different conditions. Vital stainings and TBUT correlated best with one another whereas the best test combination to detect DED was: OSDI/TBUT/Schirmer.
dc.description9
dc.description5
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundacao de Apoio ao Ensino, Pesquisa e AssistAancia do Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (FAEPA)
dc.descriptionNAP-FTO USP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherPublic Library Science
dc.publisherSan Francisco
dc.publisherEUA
dc.relationPlos One
dc.relationPLoS One
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectOcular Surface Disease
dc.subjectType-2 Diabetic-patients
dc.subjectTear Film Function
dc.subjectLacrimal Gland
dc.subjectSjogrens-syndrome
dc.subjectClinical Correlations
dc.subjectWorkshop 2007
dc.subjectIndex
dc.subjectClassification
dc.subjectSubcommittee
dc.titleComparison of Diagnostic Tests in Distinct Well-Defined Conditions Related to Dry Eye Disease
dc.typeArtículos de revistas


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